Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | DRD1 | P21728 | 5/20 | 0.50 |
| ▸ | DRD5 | P21918 | 5/20 | 0.50 |
| ▸ | DRD3 | P35462 | 5/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.47 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3153213 | 0.84 | KMT2A (0.52) | POLBALDH1A1KMT2A | |
| SCHEMBL29338289 | 0.81 | ESR1 (0.56) | ESR1ESR2DRD2DRD1DRD5 | |
| SCHEMBL10351344 | 0.78 | ESR1 (0.62) | ESR1ESR2DRD2DRD1DRD5 | |
| SCHEMBL23745365 | 0.77 | ESR1 (0.43) | ESR1ESR2DRD2DRD1DRD5 | |
| SCHEMBL3149736 | 0.77 | DPP4 (0.46) | MTNR1BKMT2A | |
| SCHEMBL11455526 | 0.77 | KMT2A (0.66) | ESR1ESR2DRD2DRD1DRD5 | |
| SCHEMBL10400059 | 0.76 | ESR1 (0.64) | ESR1ESR2DRD1DRD5ABHD6 | |
| Hydrochloric Acid SCHEMBL4250876 | 0.76 | DPP4 (0.45) | MTNR1BKDM4EALDH1A1KMT2A | |
| SCHEMBL31566079 | 0.76 | KDM4E (0.44) | ESR1ESR2ABHD6KDM4EALDH1A1 | |
| SCHEMBL10678740 | 0.75 | ESR1 (0.59) | ESR1ESR2HDAC1MTNR1BABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |