Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362841 | 0.83 | KDM4E (1.00) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL2464129 | 0.82 | MEN1 (1.00) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL8076506 | 0.81 | MEN1 (0.72) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL8084587 | 0.80 | KMT2A (0.67) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL17609437 | 0.80 | POLB (0.68) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL17620472 | 0.79 | MEN1 (0.65) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL3259092 | 0.78 | KMT2A (0.64) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL8076523 | 0.78 | MEN1 (0.64) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL17406893 | 0.78 | KMT2A (0.65) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL17609473 | 0.78 | POLB (0.71) | MEN1KMT2ANPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756110-B1 | 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES, AS WELL AS THEIR THERAPEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR PRODUCTION THE ACTIVE AGENT | SZOLCSANYI JANOS (HU) | 2010-03-31 | — | — | EP | disclosed |
| US-20080214583-A1 | 7H-Pyrrolo[2,3-D]Pyrimidine Derivatives, As Well As Their Therapeutically Acceptable Salts, Pharmaceutical Preparations Containing Them And Process For Production The Active Agent | SZOLCSANYI JANOS | 2008-09-04 | — | — | US | disclosed |
| CN-1972946-A | 7H-pyrrolo [2, 3-d ] pyrimidine derivatives and their therapeutically acceptable salts, pharmaceutical preparations containing them and process for preparing the active substances | SZOLCSANYI JANOS (HU) | 2007-05-30 | — | — | CN | disclosed |
| EP-1756110-A1 | 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES, AS WELL AS THEIR THERAPEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR PRODUCTION THE ACTIVE AGENT | Szolcsanyi, Janos (HU) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005105804-A1 | 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES, AS WELL AS THEIR THERAPEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR PRODUCTION THE ACTIVE AGENT | SZOLCSANYI JANOS (HU) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214583-A1 | 7H-Pyrrolo[2,3-D]Pyrimidine Derivatives, As Well As Their Therapeutically Acceptable Salts, Pharmaceutical Preparations Containing Them And Process For Production The Active Agent | TYMS, DPYD, P2RX7 | MEN1 4329/4885KMT2A 4357/4885NPC1 2732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.