Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30016479 | 0.82 | PTPRC (0.54) | KMT2AMEN1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL14011196 | 0.82 | KMT2A (0.49) | KMT2AMEN1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL18769941 | 0.82 | PTPRC (0.54) | KMT2AMEN1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL11724672 | 0.81 | KMT2A (0.65) | KMT2AMEN1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL8484733 | 0.80 | ALDH1A1 (0.49) | KMT2AMEN1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL13647657 | 0.76 | DAO (0.47) | KMT2ASMN1; SMN2ALDH1A1POLBL3MBTL1 | |
| SCHEMBL11826469 | 0.75 | FFAR1 (0.47) | KMT2AMEN1SMN1; SMN2POLBCYP1A2 | |
| SCHEMBL30786238 | 0.75 | PTPRG (0.44) | KMT2AMEN1SMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL30786144 | 0.75 | FFAR1 (0.47) | KMT2AMEN1SMN1; SMN2POLBCYP1A2 | |
| SCHEMBL31190735 | 0.73 | KMT2A (0.46) | KMT2ASMN1; SMN2ALDH1A1POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807393-B1 | DIARYLSULFONES AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME (GB) | 2010-03-31 | — | — | EP | disclosed |
| US-20090170824-A1 | Diarylsulfones as 5-HT2A Antagonists | CASTRO PINEIRO JOSE LUIS | 2009-07-02 | — | — | US | disclosed |
| US-7468393-B2 | Diarylsulfones as 5-HT2A antagonists | MERCK SHARP & DOHME LTD. (GB) | 2008-12-23 | — | — | US | disclosed |
| US-20070203205-A1 | Diarylsulfones as 5-HT2A antagonists | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2007-08-30 | — | — | US | disclosed |
| EP-1807393-A1 | DIARYLSULFONES AS 5-HT2A ANTAGONISTS | Merck Sharp & Dohme Limited (GB) | 2007-07-18 | — | — | EP | disclosed |
| US-7217740-B2 | Diarylsulfones as 5-HT2A antagonists | MERCK SHARP AND DOHME | 2007-05-15 | — | — | US | disclosed |
| US-20060052445-A1 | Diarylsulfones as 5-HT2A antagonists | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2006-03-09 | — | — | US | disclosed |
| WO-2006021805-A1 | DIARYLSULFONES AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2006-03-02 | — | — | WO | disclosed |
| US-6013839-A | REACTING A 2,4-DIHALOACETOPHENONE WITH A THIOLATING AGENT UNDER ANHYDROUS CONDITIONS; EFFICIENCY; INTERMEDIATES OF HERBICIDES E.G., BENZAMIDE DERIVATIVES | RHONE-POULENC AGRICULTURE LIMITED (GB) | 2000-01-11 | — | — | US | disclosed |
| EP-0883605-A1 | PROCESS FOR PREPARING 2-(THIOSUBSTITUTED)-4-HALOACETOPHENONES | RHONE-POULENC AGRICULTURE LTD. (GB) | 1998-12-16 | — | — | EP | disclosed |
| EP-0536512-B1 | A method and intermediates for the preparation of 6-fluorobenzisothiazoles | HOECHST MARION ROUSSEL INC (US) | 1997-11-05 | — | — | EP | disclosed |
| WO-1997030026-A1 | PROCESS FOR PREPARING 2-(THIOSUBSTITUTED)-4-HALOACETOPHENONES | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1997-08-21 | — | — | WO | disclosed |
| EP-0536512-A1 | A method and intermediates for the preparation of 6-fluorobenzisothiazoles | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-04-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203205-A1 | Diarylsulfones as 5-HT2A antagonists | HTR2A, HTR2B, HTR1A | KMT2A 1125/4885MEN1 1826/4885SMN1; SMN2 762/4885 |
| US-20060052445-A1 | Diarylsulfones as 5-HT2A antagonists | HTR2A, HTR2B, HTR1A | KMT2A 1125/4885MEN1 1826/4885SMN1; SMN2 762/4885 |
| US-20090170824-A1 | Diarylsulfones as 5-HT2A Antagonists | HTR2A, HTR2B, HTR1A | KMT2A 1125/4885MEN1 1826/4885SMN1; SMN2 762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.