Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3157608 | 1.00 | ALDH1A1 (0.42) | ALDH1A1TUBB1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL11744106 | 0.83 | NPC1 (0.54) | ALDH1A1TUBB1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13521557 | 0.81 | NPC1 (0.58) | ALDH1A1TUBB1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7820867 | 0.80 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2NPC1RAB9ACASP3 | |
| SCHEMBL7820864 | 0.80 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2NPC1RAB9ACASP3 | |
| SCHEMBL1937074 | 0.79 | ALDH1A1 (0.50) | ALDH1A1TUBB1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2166114 | 0.79 | ALDH1A1 (0.50) | ALDH1A1TUBB1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1937076 | 0.79 | ALDH1A1 (0.50) | ALDH1A1TUBB1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL19765536 | 0.77 | ALDH1A1 (0.40) | ALDH1A1TUBB1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL22050816 | 0.77 | TUBB1 (0.46) | ALDH1A1TUBB1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753719-B1 | SUBSTITUTED PYRROLIDINE-2-ONES | NOVARTIS AG (CH) | 2010-03-03 | — | — | EP | disclosed |
| US-20070172421-A1 | Substituted pyrrolidine-2-ones | NOVARTIS AG (CH) | 2007-07-26 | — | — | US | disclosed |
| CN-1960971-A | Substituted pyrrolidine-2-ones | NOVARTIS AG (CH) | 2007-05-09 | — | — | CN | disclosed |
| EP-1753719-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | Novartis AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005118535-A1 | SUBSTITUTED PYRROLIDINE-2-ONES | NOVARTIS AG (CH) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070172421-A1 | Substituted pyrrolidine-2-ones | PRLHR, EPOR, FLT1 | ALDH1A1 567/4885TUBB1 2736/4885SMN1; SMN2 3017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.