Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPFFR1 | Q9GZQ6 | 3/20 | 0.38 |
| ▸ | NPFFR2 | Q9Y5X5 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820867 | 1.00 | ALDH1A1 (0.39) | ALDH1A1NPFFR1NPFFR2MAPK1MAPT | |
| SCHEMBL111119 | 0.82 | ALDH1A1 (0.46) | ALDH1A1NPFFR1NPFFR2MAPK1MAPT | |
| SCHEMBL648157 | 0.82 | ALDH1A1 (0.46) | ALDH1A1NPFFR1NPFFR2MAPK1MAPT | |
| SCHEMBL10254351 | 0.82 | MAOB (0.42) | ALDH1A1NPFFR1NPFFR2MAPK1MAPT | |
| SCHEMBL113975 | 0.82 | ALDH1A1 (0.46) | ALDH1A1NPFFR1NPFFR2MAPK1MAPT | |
| SCHEMBL3157608 | 0.80 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBHTTHPGD | |
| SCHEMBL3157604 | 0.80 | ALDH1A1 (0.42) | ALDH1A1MAPTPOLBHTTHPGD | |
| SCHEMBL20763631 | 0.79 | SRC (0.53) | ALDH1A1NPFFR1NPFFR2MAPK1MAPT | |
| SCHEMBL5342224 | 0.79 | SRC (0.53) | ALDH1A1NPFFR1NPFFR2MAPK1MAPT | |
| SCHEMBL24666526 | 0.78 | MGAM (0.40) | NPFFR1NPFFR2MAPK1POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799226-B1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-02-07 | — | — | EP | disclosed |
| US-5972951-A | Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists | SMITHKLINE BEECHAM PLC (GB) | 1999-10-26 | — | — | US | disclosed |
| EP-0799226-A1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019477-A1 | TETRACYCLIC SPIRO COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | disclosed |