Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL28324348 | 1.00 | HIF1A (0.67) | — | |
| Aziridine SCHEMBL8129199 | 0.94 | — | — | |
| Piperazine SCHEMBL28236767 | 0.88 | — | — | |
| SCHEMBL28437210 | 0.88 | HIF1A (0.86) | — | |
| Piperazine SCHEMBL28116810 | 0.87 | HIF1A (0.50) | — | |
| Piperazine SCHEMBL7021306 | 0.82 | — | — | |
| SCHEMBL5033222 | 0.82 | HIF1A (1.00) | — | |
| SCHEMBL2373879 | 0.82 | HIF1A (1.00) | — | |
| SCHEMBL3999265 | 0.82 | HIF1A (1.00) | — | |
| Piperazine SCHEMBL734764 | 0.82 | HIF1A (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106866508-B | A kind of method that catalysis oxidation heteroaromatic primary alconol prepares heteroaromatic aldehyde | 大连理工大学 | 2019-04-23 | — | — | CN | claimed |
| CN-106866508-A | A kind of method that catalysis oxidation heteroaromatic primary alconol prepares heteroaromatic aldehyde | 大连理工大学 | 2017-06-20 | — | — | CN | claimed |
| CN-102914506-B | Novel method for evaluating lucid ganoderma extract quality | INST OF EDIBLE FUNGI FUJIAN ACADEMY OF AGRICULTURAL SCIENCES | 2015-05-20 | — | — | CN | claimed |
| CN-102914506-A | Novel method for evaluating lucid ganoderma extract quality | INST OF EDIBLE FUNGI FUJIAN ACADEMY OF AGRICULTURAL SCIENCES | 2013-02-06 | — | — | CN | claimed |
| CN-1131846-C | Technique for treating sewage by electric dialysis with fast-conductor membrane of biological ions | XU YUJIN (CN) | 2003-12-24 | — | — | CN | claimed |
| CN-1245148-A | Technique for treating sewage by electric dialysis with fast-conductor membrane of biological ions | XU YUJIN (CN) | 2000-02-23 | — | — | CN | claimed |
| CN-116254059-B | Chemical mechanical polishing composition for edge polishing | 昂士特科技(深圳)有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-115926629-B | Chemical mechanical polishing composition with improved recycling properties | 昂士特科技(深圳)有限公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-116254059-A | Chemical mechanical polishing composition for edge polishing | 昂士特科技(深圳)有限公司 | 2023-06-13 | — | — | CN | disclosed |
| CN-115926629-A | Chemical mechanical polishing composition with improved recycle properties | 昂士特科技(深圳)有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-110590896-B | Preparation method of estrone sulfate piperazine | 上海高准医药有限公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-110590896-A | Preparation method of estrone sulfate piperazine | 上海高准医药有限公司 | 2019-12-20 | — | — | CN | disclosed |
| CN-110540528-A | novel piperazine ferulate crystal form I and preparation method thereof | CHENGDU HENGDA PHARMACEUTICAL CO LTD | 2019-12-06 | — | — | CN | disclosed |
| EP-2162135-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF USING QUINOLINONE BASED ATYPICAL ANTIPSYCHOTIC AGENTS | Reviva Pharmaceuticals, Inc. (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008144764-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF USING QUINOLINONE BASED ATYPICAL ANTIPSYCHOTIC AGENTS | REVIVA PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |
| US-20080293736-A1 | Compositions, Synthesis, and Methods of Using Quinolinone Based Atypical Antipsychotic Agents | REVIVA PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| CN-1131846-C | Technique for treating sewage by electric dialysis with fast-conductor membrane of biological ions | XU YUJIN (CN) | 2003-12-24 | — | — | CN | disclosed |
| CN-1378538-A | Diazocine-diketone derivatives and use as tryptase inhibitor thereof | BYK GULDEN LOMBERG CHEM FAB (DE) | 2002-11-06 | — | — | CN | disclosed |
| CN-1245148-A | Technique for treating sewage by electric dialysis with fast-conductor membrane of biological ions | XU YUJIN (CN) | 2000-02-23 | — | — | CN | disclosed |
| CN-1228087-A | Substituted pyrimidine derivatives and their pharmaceutical use | ZENECA LTD (GB) | 1999-09-08 | — | — | CN | disclosed |