Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
| ▸ | KDR | P35968 | 1/20 | 1.00 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4299924 | 1.00 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL577429 | 1.00 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL8199316 | 1.00 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL22003 | 1.00 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL7052601 | 1.00 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL5033222 | 1.00 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL2373879 | 1.00 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL3999265 | 1.00 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL576335 | 1.00 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL8010246 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 631 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110536892-A | New bicyclic pyrazole derivative | BAYER ANIMAL HEALTH GMBH | 2019-12-03 | — | — | CN | claimed |
| CN-105849096-B | Piperidine derivatives having multimodal activity against pain | 埃斯蒂文制药股份有限公司 | 2019-11-29 | — | — | CN | claimed |
| CN-110404420-A | A kind of composite nanometer filtering film and preparation method thereof using the water-soluble line of polyvinyl as (sacrifice) middle layer | UNIV NATIONAL DONG HWA | 2019-11-05 | — | — | CN | claimed |
| CN-110357889-A | Protein degradation target compound, its antitumor application thereof, wherein mesosome and intermediate application | 上海科技大学 | 2019-10-22 | — | — | CN | claimed |
| CN-110327796-A | A kind of preparation method of the polypiperazine-amide nanofiltration membrane of amphoteric ion modification | 浙江大学 | 2019-10-15 | — | — | CN | claimed |
| CN-106435587-B | For copper or the etching solution of copper alloy | 恩特格里斯公司 | 2019-10-01 | — | — | CN | claimed |
| CN-110256420-A | Tetrahydropyridine and pyrimidine derivatives and its preparation method and application | 江西中医药大学 | 2019-09-20 | — | — | CN | claimed |
| CN-110183669-A | A kind of amphiphilic hyper-branched structure UV matt antifouling resin preparation method and the resin | 无锡博强高分子材料科技有限公司 | 2019-08-30 | — | — | CN | claimed |
| CN-110183670-A | A kind of bipolarity dissaving polymer UV matt process for preparing resins and the resin | 无锡博强高分子材料科技有限公司 | 2019-08-30 | — | — | CN | claimed |
| CN-110183681-A | A kind of nitrogen phosphorus synergistic lignin expansion type flame retardant and preparation method thereof | 南京林业大学 | 2019-08-30 | — | — | CN | claimed |
| CN-106632066-A | Benzimidazole compound and preparation method and application thereof | 苏州旺山旺水生物医药有限公司 | 2017-05-10 | — | — | CN | claimed |
| CN-106435587-A | ETCHING SOLUTION FOR COPPER OR COPPER ALLOY | 恩特格里斯公司 | 2017-02-22 | — | — | CN | claimed |
| CN-104109885-B | Weak-alkalinity pyrophosphate solution and technology for electroplating bright tin | 广东致卓精密金属科技有限公司 | 2017-02-01 | — | — | CN | claimed |
| CN-106191887-A | Cleaning liquid composition after CMP | LTCAM株式会社 | 2016-12-07 | — | — | CN | claimed |
| CN-105954376-A | Method for extraction and derivatization of piperazine residues in tissue of fowls and pigs | 扬州大学 | 2016-09-21 | — | — | CN | claimed |
| CN-104086508-B | Nitrogenous heterocyclic 1,3,4-thiadiazoles amide derivatives and preparation and application | 贵州大学 | 2016-08-31 | — | — | CN | claimed |
| CN-104557133-B | A kind of antiseptic concrete loses anti-icing silicone materials and preparation method thereof | 江苏苏博特新材料股份有限公司 | 2016-08-17 | — | — | CN | claimed |
| CN-105777669-A | Method for preparing 2-ethyoxyl-5-(4-methyl piperazine-1-sulfonyl) benzoic acid from methyl salicylate | 锦州医科大学 | 2016-07-20 | — | — | CN | claimed |
| CN-104046246-A | Chemical Mechanical Planarization for Tungsten-Containing Substrates | AIR PROD & CHEM | 2014-09-17 | — | — | CN | claimed |
| CN-1353699-A | Substituted bicyclic heterocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents | REDDY RESEARCH FOUNDATION (IN) | 2002-06-12 | — | — | CN | claimed |