Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.35 |
| ▸ | GSTM2 | P28161 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2001815 | 0.90 | MAPT (0.35) | GSTP1GSTM2PPARGPPARAALDH1A1 | |
| SCHEMBL1994816 | 0.88 | ALDH1A1 (0.36) | GSTP1GSTM2PPARGPPARAALDH1A1 | |
| SCHEMBL1993187 | 0.85 | MTNR1A (0.34) | MTNR1AMTNR1BPPARGPPARAALDH1A1 | |
| SCHEMBL12569192 | 0.85 | HPGD (0.42) | HPGDMTNR1AMTNR1BGSTP1GSTM2 | |
| SCHEMBL1999992 | 0.76 | ACE (0.36) | PPARGPPARAALDH1A1POLBLMNA | |
| SCHEMBL1997049 | 0.75 | ITGB2 (0.34) | HPGDPPARGPPARAALDH1A1KDM4E | |
| SCHEMBL12569236 | 0.74 | MAPT (0.38) | HPGDGSTP1GSTM2ALDH1A1MAPT | |
| SCHEMBL1999450 | 0.74 | ALDH1A1 (0.39) | PPARGPPARAALDH1A1MAPTKDM4E | |
| SCHEMBL22687233 | 0.70 | PPARA (0.51) | GSTP1GSTM2PPARGPPARAALDH1A1 | |
| SCHEMBL22687231 | 0.70 | PPARA (0.51) | GSTP1GSTM2PPARGPPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029596-B1 | 2-ALKOXY-3,4,5-TRIHYDROXY-ALKYLAMIDE-BENZOTHIAZEPINES, THE PREPARATION AND USE THEREOF, AND COMPOSITIONS CONTAINING THE SAME | SANOFI AVENTIS (FR) | 2010-02-24 | — | — | EP | disclosed |