Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CXCR5 | P32302 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1596383 | 1.00 | SLC6A4 (0.42) | SLC6A4SLC6A2SLC6A3HTR1AHTR2C | |
| SCHEMBL1596640 | 0.88 | SLC6A2 (0.40) | SLC6A4SLC6A2SLC6A3HTR1AHTR2C | |
| SCHEMBL14500631 | 0.83 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3HTR2CKCNH2 | |
| SCHEMBL6989780 | 0.77 | SLC6A2 (0.46) | SLC6A4SLC6A2SLC6A3HTR2CKCNH2 | |
| SCHEMBL9802763 | 0.74 | NPSR1 (0.42) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL4597697 | 0.72 | SCN4A (0.42) | SLC6A4KCNH2CXCR5 | |
| Methanesulfonamide SCHEMBL6999861 | 0.71 | CA2 (0.44) | SLC6A4SLC6A2HTR2C | |
| SCHEMBL3304652 | 0.70 | SLC6A4 (0.42) | SLC6A4SLC6A2SLC6A3HTR1AHTR2C | |
| SCHEMBL1597694 | 0.69 | MEN1 (0.36) | SLC6A4KCNH2CXCR5ADRA2AADRA2B | |
| SCHEMBL14009255 | 0.69 | SCN4A (0.47) | SLC6A4KCNH2CXCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749001-B1 | 3-PIPERIDINYLISOCHROMAN-5-OLS AS DOPAMINE AGONISTS | AVENTIS PHARMA INC (US) | 2010-03-03 | — | — | EP | disclosed |