Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.72 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | MTOR | P42345 | 1/20 | 0.59 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.59 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.59 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.48 |
| ▸ | ALB | P02768 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.48 |
| ▸ | POLA1 | P09884 | 1/20 | 0.48 |
| ▸ | ADA | P00813 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12621417 | 1.00 | PDE3A (0.72) | PDE3APDE4DSLC29A1LMNATHRB | |
| SCHEMBL18561534 | 1.00 | PDE3A (0.72) | PDE3APDE4DSLC29A1LMNATHRB | |
| SCHEMBL29325152 | 1.00 | PDE3A (0.72) | PDE3APDE4DSLC29A1LMNATHRB | |
| SCHEMBL18537397 | 1.00 | PDE3A (0.72) | PDE3APDE4DSLC29A1LMNATHRB | |
| SCHEMBL12151832 | 1.00 | PDE3A (0.72) | PDE3APDE4DSLC29A1LMNATHRB | |
| SCHEMBL12149492 | 1.00 | PDE3A (0.72) | PDE3APDE4DSLC29A1LMNATHRB | |
| SCHEMBL12150864 | 1.00 | PDE3A (0.72) | PDE3APDE4DSLC29A1LMNATHRB | |
| SCHEMBL18561536 | 1.00 | PDE3A (0.72) | PDE3APDE4DSLC29A1LMNATHRB | |
| SCHEMBL21006620 | 1.00 | PDE3A (0.72) | PDE3APDE4DSLC29A1LMNATHRB | |
| SCHEMBL141004 | 1.00 | PDE3A (0.72) | PDE3APDE4DSLC29A1LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645745-B2 | Propionic Acid (2R,3R,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-hydroxy-4-methyl-3-propionyloxy-tetrahydro-furan-2-ylmethyl ester; inhibit RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase | ROCHE PALO ALTO LLC (US) | 2010-01-12 | — | — | US | disclosed |
| EP-2004634-A1 | 3',5'-DI-O-ACYLATED NUCLEOSIDES FOR HCV TREATMENT | F.HOFFMANN-LA ROCHE AG (CH) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007113159-A1 | 3',5'-DI-O-ACYLATED NUCLEOSIDES FOR HCV TREATMENT | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-11 | — | — | WO | disclosed |
| US-20070232562-A1 | Antiviral nucleosides | ROCHE PALO ALTO LLC | 2007-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232562-A1 | Antiviral nucleosides | RNGTT, PNP, NSUN2 | PDE3A 1146/4885PDE4D 2129/4885SLC29A1 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.