Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Adenine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.71 |
| ▸ | PI4KA | P42356 | 2/20 | 0.71 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.71 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.71 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.71 |
| ▸ | XDH | P47989 | 1/20 | 0.71 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenine SCHEMBL385842 | 0.88 | LMNA (0.92) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL14125908 | 0.87 | PI4KA (0.76) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL28763032 | 0.87 | PI4KA (0.76) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL31591098 | 0.87 | PI4KA (0.76) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL9621210 | 0.86 | PI4KA (0.81) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL10790462 | 0.85 | PI4KA (0.63) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL1331751 | 0.84 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL8111 | 0.84 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL3414606 | 0.84 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL29442902 | 0.84 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106146561-A | A kind of synthetic method of tenofovir | 浙江九洲药业股份有限公司 | 2016-11-23 | — | — | CN | claimed |
| CN-107737335-B | Microbubble complexes and methods of use | 通用电气公司 | 2023-08-29 | — | — | CN | disclosed |
| CN-115701349-A | Solid beverage for treating gout and preparation method thereof | 深圳枫语生物医药科技有限公司 | 2023-02-10 | — | — | CN | disclosed |
| CN-114617868-A | NRF2 activating compounds and uses thereof | 参宿七制药股份有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-108699011-B | NRF2 activating compounds and uses thereof | 参宿七制药股份有限公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-106573901-B | Fumarate analogues and their use in the treatment of autoimmune or inflammatory diseases | 参宿七制药股份有限公司 | 2021-03-02 | — | — | CN | disclosed |
| CN-108699034-B | NRF2 activating compounds and uses thereof | 参宿七制药股份有限公司 | 2020-12-11 | — | — | CN | disclosed |
| CN-112004808-A | Prodrugs of NRF 2-activating compounds and uses thereof | 参宿七制药股份有限公司 | 2020-11-27 | — | — | CN | disclosed |
| CN-111000973-A | Composition with gout improving effect and application thereof | 重庆申高生化制药股份有限公司 | 2020-04-14 | — | — | CN | disclosed |
| CN-106146561-A | A kind of synthetic method of tenofovir | 浙江九洲药业股份有限公司 | 2016-11-23 | — | — | CN | disclosed |