Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.52 |
| ▸ | KDM1A | O60341 | 4/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | EED | O75530 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301711 | 0.87 | SLC6A4 (0.58) | SLC6A2SLC6A4DRD2DRD3SLC6A3 | |
| SCHEMBL4238409 | 0.84 | SLC6A2 (0.66) | SLC6A2SLC6A4SLC6A3KDM1AMAP2K1 | |
| SCHEMBL13837634 | 0.84 | SLC6A2 (0.67) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 | |
| SCHEMBL2267290 | 0.84 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3KDM1AMAP2K1 | |
| SCHEMBL3444195 | 0.84 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3KDM1AMAP2K1 | |
| SCHEMBL3251306 | 0.83 | SLC6A2 (0.72) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 | |
| Hydrochloric Acid SCHEMBL9555741 | 0.83 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KDM1AMAP2K1 | |
| SCHEMBL1848360 | 0.82 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3KCNH2HTR3A | |
| SCHEMBL13107011 | 0.82 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3MAP2K1EED | |
| SCHEMBL13107014 | 0.82 | EED (0.67) | SLC6A2SLC6A4SLC6A3KDM1AMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741934-B2 | Inhibitors of ion channels | PFIZER LIMITED (GB) | 2014-06-03 | — | — | US | disclosed |
| US-8741934-B2 | Inhibitors of ion channels | PFIZER LIMITED (GB) | 2014-06-03 | — | — | US | disclosed |
| US-20130072471-A1 | Inhibitors of Ion Channels | MARRON BRIAN EDWARD (US) | 2013-03-21 | — | — | US | disclosed |
| US-20130072471-A1 | Inhibitors of Ion Channels | MARRON BRIAN EDWARD (US) | 2013-03-21 | — | — | US | disclosed |
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| EP-1995241-B1 | Inhibitors of ion channels | ICAGEN INC (US) | 2010-03-17 | — | — | EP | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| EP-1995241-A1 | Inhibitors of ion channels | ICAgen, Incorporated (US) | 2008-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072471-A1 | Inhibitors of Ion Channels | TRPV1, TRPV5, TRPA1 | SLC6A2 218/4885SLC6A4 207/4885DRD2 3064/4885 |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | SLC6A2 218/4885SLC6A4 207/4885DRD2 3064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.