Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 8/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31594216 | 0.89 | CXCR2 (0.46) | CXCR2CXCR1CYP2C9HSD17B10PTGS1 | |
| SCHEMBL31594646 | 0.87 | CXCR2 (0.47) | CXCR2CXCR1CYP2C9HSD17B10MAPK14 | |
| SCHEMBL22616763 | 0.85 | CXCR2 (0.46) | CXCR2HPGDCXCR1KDM4EALDH1A1 | |
| SCHEMBL29604502 | 0.85 | CXCR2 (0.46) | CXCR2HPGDCXCR1KDM4EALDH1A1 | |
| SCHEMBL31594086 | 0.85 | CXCR2 (0.47) | CXCR2CXCR1CYP2C9MAPK14 | |
| SCHEMBL31594232 | 0.84 | CXCR2 (0.43) | CXCR2HPGDCXCR1CYP1A2CYP2C19 | |
| SCHEMBL31594230 | 0.84 | CXCR2 (0.43) | CXCR2TSHRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL31594637 | 0.83 | CXCR2 (0.50) | CXCR2CXCR1CYP2C9HSD17B10PTGS1 | |
| SCHEMBL31594107 | 0.83 | CXCR2 (0.44) | CXCR2HPGDCXCR1CYP3A4CYP2C19 | |
| SCHEMBL31594554 | 0.83 | CXCR2 (0.46) | CXCR2HPGDCXCR1SMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250170141-A1 | MRGPRX2 MODULATORS AND RELATED METHODS OF TREATMENT | INCYTE CORPORATION | 2025-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250170141-A1 | MRGPRX2 MODULATORS AND RELATED METHODS OF TREATMENT | MRGPRX2, MRGPRX1, MRGPRX4 | CXCR2 763/4885HPGD 1357/4885TSHR 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.