Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 3/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929456 | 0.80 | PDK2 (0.37) | HSD11B1 | |
| SCHEMBL733177 | 0.77 | HSD11B1 (0.54) | HSD11B1OPRL1OPRM1OPRK1SLC6A4 | |
| SCHEMBL16719380 | 0.72 | OPRL1 (0.64) | HSD11B1OPRL1OPRM1OPRK1SLC6A4 | |
| SCHEMBL735185 | 0.70 | OPRM1 (0.50) | HSD11B1OPRL1OPRM1OPRK1SLC6A4 | |
| SCHEMBL25787927 | 0.70 | OPRL1 (0.65) | HSD11B1OPRL1OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL733924 | 0.70 | OPRM1 (0.49) | HSD11B1OPRL1OPRM1OPRK1SLC6A4 | |
| SCHEMBL3351276 | 0.69 | OPRL1 (0.57) | HSD11B1OPRL1OPRM1OPRK1SLC6A4 | |
| SCHEMBL3351315 | 0.69 | OPRL1 (0.57) | HSD11B1OPRL1OPRM1OPRK1SLC6A4 | |
| SCHEMBL12321753 | 0.69 | OPRL1 (0.57) | HSD11B1OPRL1OPRM1OPRK1SLC6A4 | |
| SCHEMBL3348838 | 0.69 | OPRL1 (0.57) | HSD11B1OPRL1OPRM1OPRK1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | GRUNENTHAL GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009986-A1 | SUBSTITUTED HETEROARYL DERIVATIVES | CYP3A43, HMGCR, ABCG2 | HSD11B1 967/4885OPRL1 1562/4885OPRM1 1029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.