Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.33 |
| ▸ | UCHL1 | P09936 | 5/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31600727 | 0.81 | JAK3 (0.38) | JAK3RETDDB1CRBNNR1H2 | |
| SCHEMBL31600061 | 0.79 | PIK3R1 (0.32) | JAK3PIK3R1PIK3CA | |
| SCHEMBL31600874 | 0.79 | PIK3CA (0.31) | JAK3PIK3R1PIK3CA | |
| SCHEMBL31600960 | 0.78 | RET (0.32) | JAK3RET | |
| SCHEMBL31599909 | 0.77 | EIF2AK4 (0.41) | PIK3R1PIK3CACHRNA7PIK3CDPIK3CB | |
| SCHEMBL31600565 | 0.75 | JAK3 (0.36) | JAK3RET | |
| SCHEMBL31600865 | 0.74 | RET (0.36) | JAK3RETUCHL1 | |
| SCHEMBL31600240 | 0.73 | NR1H2 (0.49) | UCHL1CHRNA7NOTUMNR1H2NR1H3 | |
| SCHEMBL31599864 | 0.72 | JAK3 (0.43) | JAK3RETDDB1CRBNNR1H2 | |
| SCHEMBL31599924 | 0.71 | HDAC1 (0.46) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025111547-A1 | 2,3-DIHYDROPYROLLOPYRIDINE CARBOXAMIDE COMPOUNDS AND METHODS OF USE THEREOF | RGENTA THERAPEUTICS, INC. (US) | 2025-05-30 | — | — | WO | disclosed |