Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | AKT1S1 | Q96B36 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.31 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31599864 | 0.91 | JAK3 (0.43) | JAK3RETDDB1CRBNNR1H2 | |
| SCHEMBL31599955 | 0.86 | DDB1 (0.35) | JAK3DDB1CRBNNR1H2NR1H3 | |
| SCHEMBL31600178 | 0.81 | JAK3 (0.37) | JAK3RETDDB1CRBNNR1H2 | |
| SCHEMBL31600221 | 0.81 | DDB1 (0.46) | DDB1CRBNAKT1CFTRACHE | |
| SCHEMBL31600722 | 0.77 | GPR119 (0.44) | RETDDB1CRBNNR1H2GPR119 | |
| SCHEMBL10325519 | 0.76 | JAK3 (0.52) | JAK3RETAKT1AKT1S1 | |
| SCHEMBL31600206 | 0.75 | EIF2AK4 (0.43) | DDB1CRBNIDH1GPR119EIF2AK4 | |
| SCHEMBL31599849 | 0.75 | MAP4K4 (0.47) | DDB1CRBNNR1H2NR1H3GPR119 | |
| SCHEMBL31600921 | 0.75 | MAP4K4 (0.47) | DDB1CRBNNR1H2NR1H3GPR119 | |
| SCHEMBL31599830 | 0.75 | MAP4K4 (0.47) | DDB1CRBNNR1H2NR1H3GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025111547-A1 | 2,3-DIHYDROPYROLLOPYRIDINE CARBOXAMIDE COMPOUNDS AND METHODS OF USE THEREOF | RGENTA THERAPEUTICS, INC. (US) | 2025-05-30 | — | — | WO | disclosed |