Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.75 |
| ▸ | PKM | P14618 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.75 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.75 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.75 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.75 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL19118816 | 0.98 | KDM4E (0.73) | KDM4EPKMLMNAADORA3ADORA2A | |
| SCHEMBL4775643 | 0.87 | KDM4E (0.64) | KDM4EPKMLMNAADORA3ADORA2A | |
| SCHEMBL10242704 | 0.87 | KDM4E (0.73) | KDM4EPKMLMNAADORA3ADORA2A | |
| SCHEMBL6314682 | 0.86 | PKM (0.75) | KDM4EPKMLMNAADORA3ADORA2A | |
| SCHEMBL6320885 | 0.86 | HPGD (0.81) | KDM4EPKMLMNAADORA3ADORA2A | |
| SCHEMBL193027 | 0.86 | KDM4E (0.71) | KDM4EPKMLMNAADORA3ADORA2A | |
| SCHEMBL5010589 | 0.86 | KDM4E (1.00) | KDM4EPKMLMNAADORA3ADORA2A | |
| SCHEMBL3327114 | 0.85 | PKM (1.00) | KDM4EPKMLMNAADORA3ADORA2A | |
| SCHEMBL26843132 | 0.84 | PKM (0.59) | KDM4EPKMLMNAADORA3ADORA2A | |
| SCHEMBL6314841 | 0.84 | PKM (0.72) | KDM4EPKMLMNAADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963313-B1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE (DGAT) | MADRIGAL PHARMACEUTICALS INC (US) | 2012-11-14 | — | — | EP | claimed |
| EP-1745009-B1 | HETEROARYL SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2012-11-14 | — | — | EP | claimed |
| CN-101903339-B | Substituted N-phenyl-bipyrrolidine carboxamides and their therapeutic use | SANOFI AVENTIS | 2012-06-27 | — | — | CN | claimed |
| EP-2197875-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Via Pharmaceuticals, Inc. (US) | 2010-06-23 | — | — | EP | claimed |
| US-20100137312-A1 | NOVEL AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | claimed |
| EP-2148868-A1 | NOVEL AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | NeuroSearch A/S (DK) | 2010-02-03 | — | — | EP | claimed |
| CN-100488962-C | Derivative of thiadiazoles containing cyclo oxdiazole, synthetic method, and biological activity | UNIV NANKAI (CN) | 2009-05-20 | — | — | CN | claimed |
| WO-2009037222-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2009-03-26 | — | — | WO | claimed |
| CN-101316844-A | Inhibitors of diacylglycerol acyltransferase (DGAT) | HOFFMANN LA ROCHE (CH) | 2008-12-03 | — | — | CN | claimed |
| WO-2008138917-A1 | NOVEL AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-11-20 | — | — | WO | claimed |
| EP-1754705-A2 | Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders | Genentech, Inc. (US) | 2007-02-21 | — | — | EP | claimed |
| EP-1745009-A1 | HETEROARYL SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2007-01-24 | — | — | EP | claimed |
| JP-2006513192-A | — | — | 2006-04-20 | — | — | JP | claimed |
| WO-2005110971-A1 | HETEROARYL SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | claimed |
| CN-1665808-A | Thiadiazoles or oxadiazoles and their use as inhibitors of JAK protein kinase | VERTEX PHARMA (US) | 2005-09-07 | — | — | CN | claimed |
| WO-2005019168-A2 | FLUORINATED LYSINE DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-03-03 | — | — | WO | claimed |
| US-20050043292-A1 | Fluorinated lysine derivatives as dipeptidyl peptidase IV inhibitors | PFIZER INC | 2005-02-24 | — | — | US | claimed |
| EP-1501829-A1 | THIADIAZOLES OR OXADIAZOLES AND THEIR USE AS INHIBITORS OF JAK PROTEIN KINASE | Vertex Pharmaceuticals Incorporated (US) | 2005-02-02 | — | — | EP | claimed |
| WO-2004058753-A1 | THIADIAZOLES OR OXADIAZOLES AND THEIR USE AS INHIBITORS OF JAK PROTEIN KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2004-07-15 | — | — | WO | claimed |
| US-20040038992-A1 | Inhibitors of Jak protein kinase | VERTEX PHARMACEUTICALS INCORPORATED | 2004-02-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043292-A1 | Fluorinated lysine derivatives as dipeptidyl peptidase IV inhibitors | DPP4, DPP7, ALPI | KDM4E 196/4885PKM 43/4885LMNA 2354/4885 |
| US-20040038992-A1 | Inhibitors of Jak protein kinase | JAK2, JAK1, JAK3 | KDM4E 992/4885PKM 744/4885LMNA 4037/4885 |
| US-20100137312-A1 | NOVEL AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS | KCNH1, KCNJ2, KCNN2 | KDM4E 711/4885PKM 455/4885LMNA 3540/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.