Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 15/20 | 0.55 |
| ▸ | FOLR1 | P15328 | 11/20 | 0.55 |
| ▸ | SLC46A1 | Q96NT5 | 11/20 | 0.55 |
| ▸ | FOLR2 | P14207 | 8/20 | 0.55 |
| ▸ | ATIC | P31939 | 1/20 | 0.54 |
| ▸ | SLC19A1 | P41440 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12011014 | 0.95 | GART (0.51) | GARTFOLR1SLC46A1FOLR2ATIC | |
| SCHEMBL1604405 | 0.85 | GART (0.73) | GARTFOLR1SLC46A1FOLR2SLC19A1 | |
| SCHEMBL3159760 | 0.85 | FOLR1 (0.72) | GARTFOLR1SLC46A1FOLR2ATIC | |
| SCHEMBL3160560 | 0.85 | GART (0.60) | GARTFOLR1SLC46A1FOLR2ATIC | |
| SCHEMBL3156341 | 0.85 | FOLR1 (0.54) | GARTFOLR1SLC46A1FOLR2SLC19A1 | |
| SCHEMBL3165312 | 0.85 | GART (0.72) | GARTFOLR1SLC46A1FOLR2ATIC | |
| SCHEMBL3157031 | 0.85 | GART (0.72) | GARTFOLR1SLC46A1FOLR2ATIC | |
| SCHEMBL3153255 | 0.84 | GART (0.77) | GARTFOLR1SLC46A1FOLR2ATIC | |
| SCHEMBL3153230 | 0.84 | GART (0.77) | GARTFOLR1SLC46A1FOLR2ATIC | |
| SCHEMBL3161181 | 0.84 | FOLR1 (0.73) | GARTFOLR1SLC46A1FOLR2ATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-07-06 | — | — | US | disclosed |
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-07-06 | — | — | US | disclosed |
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2020-06-18 | — | — | US | disclosed |
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2020-06-18 | — | — | US | disclosed |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-04-07 | — | — | US | disclosed |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-04-07 | — | — | US | disclosed |
| US-20180346474-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-12-06 | — | — | US | disclosed |
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-19 | — | — | US | disclosed |
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-19 | — | — | US | disclosed |
| EP-2995199-B1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | UNIV HOLY GHOST DUQUESNE (US) | 2018-03-14 | — | — | EP | disclosed |
| EP-2995199-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | Duquesne University of The Holy Spirit (US) | 2016-03-16 | — | — | EP | disclosed |
| EP-2348843-B1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | UNIV HOLY GHOST DUQUESNE (US) | 2015-11-11 | — | — | EP | disclosed |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-11-22 | — | — | US | disclosed |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2012-11-22 | — | — | US | disclosed |
| US-8252804-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252804-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252804-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2012-08-28 | — | — | US | disclosed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000498-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | GART 26/4885FOLR1 3/4885SLC46A1 1/4885 |
| US-10611767-B2 | Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | GART 26/4885FOLR1 3/4885SLC46A1 1/4885 |
| US-20200190097-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | GART 26/4885FOLR1 3/4885SLC46A1 1/4885 |
| US-11053252-B2 | Selective proton coupled folate transporter and folate receptor, and garftase inhibitor compounds and methods of using the same | SLC46A1, SLC19A1, FOLR1 | GART 26/4885FOLR1 3/4885SLC46A1 1/4885 |
| US-20120295926-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | GART 26/4885FOLR1 3/4885SLC46A1 1/4885 |
| US-20180346474-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | GART 26/4885FOLR1 3/4885SLC46A1 1/4885 |
| US-20100081676-A1 | SELECTIVE PROTON COUPLED FOLATE TRANSPORTER AND FOLATE RECEPTOR, AND GARFTASE INHIBITOR COMPOUNDS AND METHODS OF USING THE SAME | SLC46A1, SLC19A1, FOLR1 | GART 26/4885FOLR1 3/4885SLC46A1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.