Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25439651 | 0.85 | KDM4E (0.39) | NPC1DGAT1MAPTKDM4E | |
| SCHEMBL25375911 | 0.84 | DGAT1 (0.34) | NPC1DGAT1 | |
| SCHEMBL25433894 | 0.80 | NPC1 (0.36) | NPC1DGAT1 | |
| SCHEMBL30552869 | 0.79 | CA12 (0.35) | NPC1DGAT1KDM4EHTT | |
| SCHEMBL25374677 | 0.78 | DGAT1 (0.36) | NPC1DGAT1 | |
| SCHEMBL29324119 | 0.76 | NPC1 (0.39) | NPC1DGAT1MAPT | |
| SCHEMBL30470561 | 0.76 | NPC1 (0.39) | NPC1DGAT1MAPT | |
| SCHEMBL25432150 | 0.73 | DGAT1 (0.33) | NPC1DGAT1 | |
| SCHEMBL22220337 | 0.72 | NPC1 (0.41) | NPC1KMT2AMAPT | |
| SCHEMBL13122602 | 0.72 | TDP1 (0.41) | NPC1DGAT1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4482583-B1 | ZWITTERIONIC ANTIBACTERIAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2026-04-01 | — | — | EP | disclosed |
| US-20250179066-A1 | ZWITTERIONIC ANTIBACTERIAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2025-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250179066-A1 | ZWITTERIONIC ANTIBACTERIAL COMPOUNDS | MRPL21, WIZ, CFTR | NPC1 2861/4885DGAT1 4735/4885KMT2A 4463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.