Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | REV1 | Q9UBZ9 | 2/20 | 0.53 |
| ▸ | SLC27A1 | Q6PCB7 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3162425 | 0.94 | EGFR (0.53) | ALDH1A1USP2REV1HTTSMN1; SMN2 | |
| SCHEMBL3170421 | 0.92 | SMN1; SMN2 (0.55) | ALDH1A1USP2REV1HTTSMN1; SMN2 | |
| SCHEMBL3166249 | 0.92 | GAA (0.54) | ALDH1A1USP2SMN1; SMN2DEGS1MEN1 | |
| SCHEMBL3162806 | 0.91 | JAK3 (0.51) | ALDH1A1USP2HTTSMN1; SMN2DEGS1 | |
| SCHEMBL3175543 | 0.90 | EGFR (0.50) | ALDH1A1USP2REV1SLC27A1HTT | |
| SCHEMBL3165286 | 0.90 | USP2 (0.57) | ALDH1A1USP2REV1HTTSMN1; SMN2 | |
| SCHEMBL3258722 | 0.89 | EGFR (0.46) | ALDH1A1USP2HTTSMN1; SMN2MEN1 | |
| SCHEMBL3166342 | 0.88 | ALDH1A1 (0.57) | ALDH1A1USP2SMN1; SMN2KMT2AEGFR | |
| SCHEMBL3172699 | 0.88 | ALDH1A1 (0.51) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3171582 | 0.87 | MEN1 (0.47) | ALDH1A1USP2MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |