Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3156668 | 0.93 | MAPT (0.59) | USP2ALDH1A1TSHRLMNAMAPT | |
| SCHEMBL3162425 | 0.92 | EGFR (0.53) | USP2KDM4EALDH1A1TSHRLMNA | |
| SCHEMBL3166249 | 0.91 | GAA (0.54) | USP2KDM4EALDH1A1TSHRMAPT | |
| SCHEMBL3170421 | 0.91 | SMN1; SMN2 (0.55) | USP2KDM4EALDH1A1TSHRMEN1 | |
| SCHEMBL3162796 | 0.90 | ADORA3 (0.53) | USP2ALDH1A1TSHRADORA3MEN1 | |
| SCHEMBL3162806 | 0.90 | JAK3 (0.51) | USP2ALDH1A1TSHRLMNAMAPT | |
| SCHEMBL3161698 | 0.90 | ALDH1A1 (0.54) | USP2ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL3175543 | 0.89 | EGFR (0.50) | USP2KDM4EALDH1A1TSHRLMNA | |
| SCHEMBL3169692 | 0.89 | ADORA3 (0.47) | USP2ALDH1A1TSHRLMNAADORA3 | |
| SCHEMBL3169880 | 0.87 | ADORA3 (0.46) | USP2KDM4EALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |