Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.40 |
| ▸ | GPR6 | P46095 | 6/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL389388 | 0.90 | GPR119 (0.51) | GPR119CYP2C9 | |
| SCHEMBL3167007 | 0.80 | GPR119 (0.61) | GPR119GPR6CYP2C9 | |
| SCHEMBL3171012 | 0.77 | GPR119 (0.40) | GPR119GPR6CYP2C9 | |
| SCHEMBL3246691 | 0.74 | ACACB (0.40) | GPR119GPR6CYP2C9ERBB2EGFR | |
| SCHEMBL3252680 | 0.74 | GPR119 (0.39) | GPR119GPR6CYP2C9ERBB2EGFR | |
| SCHEMBL3167356 | 0.74 | GPR119 (0.57) | GPR119CYP2C9 | |
| SCHEMBL3252644 | 0.73 | ACACB (0.39) | GPR119GPR6CYP2C9ERBB2 | |
| SCHEMBL3253994 | 0.73 | ACACB (0.42) | GPR119ERBB2EGFR | |
| SCHEMBL3254182 | 0.73 | ACACB (0.39) | GPR119GPR6CYP2C9ERBB2EGFR | |
| SCHEMBL3246590 | 0.73 | GPR119 (0.56) | GPR119GPR6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644357-B9 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2010-03-24 | — | — | EP | claimed |
| EP-1644357-B1 | TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2007-12-12 | — | — | EP | claimed |