SCHEMBL31630916

SCHEMBL31630916

COc1ccc(N2CCN(C(=O)OC(C)(C)C)CC2)cc1N1CCC(=O)NC1=O

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 4/20 0.48
▸ CRBN Q96SW2 4/20 0.48
▸ NR3C1 P04150 1/20 0.46
▸ PGR P06401 1/20 0.46
▸ SLC6A4 P31645 1/20 0.46
▸ KCNH2 Q12809 1/20 0.46
▸ PDE3B Q13370 1/20 0.46
▸ PDE3A Q14432 1/20 0.46
▸ LMNA P02545 2/20 0.45
▸ MAPT P10636 2/20 0.45
▸ ALDH1A1 P00352 1/20 0.45
▸ PDK2 Q15119 1/20 0.45
▸ ABCB1 P08183 2/20 0.44
▸ ALK Q9UM73 5/20 0.43
▸ SUV39H2 Q9H5I1 3/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ P2RX7 Q99572 1/20 0.42
▸ SMPD3 Q9NY59 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25034753 1.00 DDB1 (0.48) DDB1CRBNNR3C1PGRSLC6A4
SCHEMBL25824549 0.92 DDB1 (0.48) DDB1CRBNNR3C1PGRSLC6A4
SCHEMBL31630927 0.87 DDB1 (0.49) DDB1CRBNLMNAMAPTALDH1A1
SCHEMBL30158207 0.86 CRBN (0.47) DDB1CRBNNR3C1PGRSLC6A4
SCHEMBL24735127 0.86 CRBN (0.47) DDB1CRBNNR3C1PGRSLC6A4
SCHEMBL30952388 0.86 DDB1 (0.50) DDB1CRBNLMNAMAPTALDH1A1
SCHEMBL30643667 0.85 DDB1 (0.49) DDB1CRBNLMNAMAPTALDH1A1
SCHEMBL29264332 0.84 DDB1 (0.51) DDB1CRBNLMNAMAPTALDH1A1
SCHEMBL22119507 0.84 DDB1 (0.59) DDB1CRBNLMNAMAPTALDH1A1
SCHEMBL24735228 0.83 MEN1 (0.51) DDB1CRBNNR3C1PGRSLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025129024-A1 CEREBLON-RECRUITING DEGRADERS OF ANTIAPOPTOTIC BCL-2 PROTEINS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2025-06-19 — — WO disclosed
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