Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | BHMT | Q93088 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GNPAT | O15228 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 7/20 | 0.44 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.44 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.44 |
| ▸ | PAM | P19021 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163154 | 1.00 | MAPT (0.48) | MAPTTHRBBLMKDM4EALOX15 | |
| SCHEMBL3163148 | 1.00 | MAPT (0.48) | MAPTTHRBBLMKDM4EALOX15 | |
| SCHEMBL3364340 | 0.84 | MAPT (0.50) | MAPTTHRBBLMKDM4EALOX15 | |
| SCHEMBL468743 | 0.84 | MAPT (0.50) | MAPTTHRBBLMKDM4EALOX15 | |
| SCHEMBL468741 | 0.84 | MAPT (0.50) | MAPTTHRBBLMKDM4EALOX15 | |
| SCHEMBL3158140 | 0.83 | MAPT (0.53) | MAPTTHRBBLMKDM4EALOX15 | |
| SCHEMBL3158146 | 0.83 | MAPT (0.53) | MAPTTHRBBLMKDM4EALOX15 | |
| SCHEMBL9636369 | 0.83 | MAPT (0.57) | MAPTTHRBBLMKDM4EALOX15 | |
| SCHEMBL9636364 | 0.83 | MAPT (0.57) | MAPTTHRBBLMKDM4EALOX15 | |
| SCHEMBL4953117 | 0.82 | MAPT (0.48) | MAPTTHRBBLMKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497525-B2 | Pneumococcal polysaccharide conjugate vaccine | MERCK & CO INC (US) | 2010-03-03 | — | — | EP | disclosed |
| EP-0497525-B1 | Pneumococcal polysaccharide conjugate vaccine | MERCK & CO INC (US) | 1998-08-19 | — | — | EP | disclosed |
| US-5623057-A | IMMUNOGENIC PROTEIN COVALENTLY LINKED TO POLYSACCHARIDE DERIVED FROM STREPTOCOCCUS PNEUMONIAE | MERCK & CO., INC. (US) | 1997-04-22 | — | — | US | disclosed |
| CN-1020733-C | PROCESS FOR PREPARING COVALENT CONJUNCT AGENT OF BACTERIAL POLYSACCHARIDE AND IMMUNOGEN PROTEIN | MC CO LTD (US) | 1993-05-19 | — | — | CN | disclosed |
| EP-0497525-A2 | Pneumococcal polysaccharide conjugate vaccine | MERCK & CO. INC. (US) | 1992-08-05 | — | — | EP | disclosed |
| EP-0467714-A1 | The class II protein of the outer membrane of neisseria meningitidis | MERCK & CO. INC. (US) | 1992-01-22 | — | — | EP | disclosed |
| EP-0161188-B1 | COVALENTLY-MODIFIED BACTERIAL POLYSACCHARIDES, STABLE COVALENT CONJUGATES OF SUCH POLYSACCHARIDES AND IMMUNOGENIC PROTEINS WITH BIGENERIC SPACERS, AND METHODS OF PREPARING SUCH POLYSACCHARIDES AND CONJUGATES AND OF CONFIRMING COVALENCY | MERCK & CO. INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4882317-A | SOLUBILIZATION | MERCK & CO., INC. (US) | 1989-11-21 | — | — | US | disclosed |
| US-4695624-A | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency | MERCK & CO., INC. (US) | 1987-09-22 | — | — | US | disclosed |
| CN-85104164-A | Preparation method of covalent conjugate of bacterial polysaccharide and immunogen protein | — | 1987-02-04 | — | — | CN | disclosed |
| EP-0161188-A2 | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency | MERCK & CO. INC. (US) | 1985-11-13 | — | — | EP | disclosed |