Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | TSPO | P30536 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4804791 | 0.81 | TDP1 (0.47) | TDP1NPBWR1LMNAMEN1KMT2A | |
| SCHEMBL31636717 | 0.77 | ABL1 (0.42) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL30993736 | 0.76 | ABL1 (0.41) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2251382 | 0.75 | ABL1 (0.35) | TDP1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8747840 | 0.75 | ABL1 (0.41) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL1035578 | 0.74 | NR4A2 (0.48) | LMNAKMT2AMAPTPOLBALDH1A1 | |
| SCHEMBL3436908 | 0.74 | ABL1 (0.42) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL24745526 | 0.73 | ATR (0.39) | LMNAMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL27666406 | 0.72 | KDM4E (0.51) | TDP1NPBWR1LMNAMEN1KMT2A | |
| SCHEMBL18756750 | 0.72 | XDH (0.51) | TDP1LMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025137158-A1 | DERIVATIVES OF ([1,2,4]TRIAZOLO[5,1-A]ISOQUINOLINE-5-CARBONYL)GLYCINATE AS PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE | AKEBIA THERAPEUTICS, INC. (US) | 2025-06-26 | — | — | WO | disclosed |