Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3166495 | 0.94 | SLC1A2 (0.44) | LMNAMAPTKDM4EMEN1KMT2A | |
| SCHEMBL3162484 | 0.92 | MAPT (0.44) | LMNAMAPTKDM4EKMT2APOLB | |
| SCHEMBL3155601 | 0.92 | ADORA2A (0.42) | MAPTADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL3164671 | 0.90 | ADORA2A (0.41) | ADORA2AADORA1ADORA2BADORA3ALDH1A1 | |
| SCHEMBL3260451 | 0.90 | SLC1A2 (0.52) | MAPTMEN1KMT2APOLBADORA3 | |
| SCHEMBL3161165 | 0.89 | ABCG2 (0.45) | POLBADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL3156119 | 0.89 | PHGDH (0.42) | LMNAMAPTMEN1KMT2APOLB | |
| SCHEMBL3174104 | 0.89 | ADORA2A (0.41) | MAPTPOLBADORA2AADORA1ADORA2B | |
| SCHEMBL3171368 | 0.88 | ADORA3 (0.45) | MAPTKDM4EMEN1KMT2AADORA2A | |
| SCHEMBL3170204 | 0.88 | KMT2A (0.43) | LMNAMAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |