Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3166495 | 0.95 | SLC1A2 (0.44) | MAPTALDH1A1ADORA2AADORA1ADORA3 | |
| SCHEMBL3155601 | 0.93 | ADORA2A (0.42) | MAPTALDH1A1ADORA2AADORA1ADORA3 | |
| SCHEMBL3163864 | 0.92 | LMNA (0.43) | MAPTALDH1A1ADORA2AADORA1ADORA3 | |
| SCHEMBL3164671 | 0.91 | ADORA2A (0.41) | ALDH1A1ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL3260451 | 0.91 | SLC1A2 (0.52) | MAPTADORA3MAPK1KMT2APOLB | |
| SCHEMBL3161165 | 0.90 | ABCG2 (0.45) | ADORA2AADORA1ADORA3ADORA2BCHRM4 | |
| SCHEMBL3174104 | 0.90 | ADORA2A (0.41) | MAPTALDH1A1ADORA2AADORA1ADORA3 | |
| SCHEMBL3171368 | 0.89 | ADORA3 (0.45) | MAPTALDH1A1SMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL3175769 | 0.88 | ADORA2A (0.45) | MAPTALDH1A1ADORA2AADORA1ADORA3 | |
| SCHEMBL3156095 | 0.88 | SLC1A2 (0.46) | ADORA2AADORA1ADORA3ADORA2BSLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |