SCHEMBL31642671

SCHEMBL31642671

ClC=Cc1c(Cl)cc2c(cnn2C2CCCCO2)c1Br

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ RXRA P19793 1/20 0.38
▸ RXRB P28702 1/20 0.38
▸ RXRG P48443 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.36
▸ LMNA P02545 1/20 0.36
▸ POLB P06746 1/20 0.36
▸ CYP4F2 P78329 2/20 0.34
▸ CYP4A11 Q02928 2/20 0.34
▸ RET P07949 1/20 0.33
▸ DGAT2 Q96PD7 1/20 0.32
▸ YTHDC1 Q96MU7 1/20 0.30
▸ CYP2C19 P33261 1/20 0.30
▸ CYP1A2 P05177 1/20 0.30
▸ HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25373201 0.91 RXRA (0.37) RXRARXRBRXRGALDH1A1LMNA
SCHEMBL30542408 0.91 RXRA (0.37) RXRARXRBRXRGALDH1A1LMNA
SCHEMBL25373206 0.91 RXRA (0.37) RXRARXRBRXRGALDH1A1LMNA
SCHEMBL30922407 0.90 ALDH1A1 (0.39) RXRARXRBRXRGALDH1A1LMNA
SCHEMBL31127808 0.89 RXRA (0.38) RXRARXRBRXRGALDH1A1LMNA
SCHEMBL30922527 0.88 RXRA (0.39) RXRARXRBRXRGALDH1A1LMNA
SCHEMBL31642907 0.88 RXRA (0.37) RXRARXRBRXRGALDH1A1LMNA
SCHEMBL31040992 0.87 RXRA (0.34) RXRARXRBRXRGALDH1A1LMNA
SCHEMBL30922541 0.85 RXRA (0.33) RXRARXRBRXRGALDH1A1LMNA
SCHEMBL21196028 0.84 RXRA (0.41) RXRARXRBRXRGALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025136346-A1 INDAZOLE CONTAINING COMPOUNDS AND METHODS OF USE AMGEN INC. (US) 2025-06-26 — — WO disclosed
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