Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 2/20 | 0.48 |
| ▸ | MIF | P14174 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2612390 | 0.84 | CYP19A1 (0.46) | CYP26A1MIFMEN1NPC1RAB9A | |
| SCHEMBL448275 | 0.83 | MIF (0.47) | CYP26A1MIFNPC1RAB9AKDM4E | |
| SCHEMBL29582798 | 0.83 | MIF (0.47) | CYP26A1MIFNPC1RAB9AKDM4E | |
| SCHEMBL10470879 | 0.81 | MIF (0.48) | CYP26A1MIFMEN1NPC1RAB9A | |
| SCHEMBL19432985 | 0.80 | DRD2 (0.39) | CYP26A1MIF | |
| SCHEMBL450942 | 0.78 | MAOB (0.56) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL453375 | 0.78 | MIF (0.47) | CYP26A1MIFCYP19A1 | |
| SCHEMBL17108416 | 0.77 | MPO (0.59) | CYP26A1MIFRAB9AKDM4ECYP19A1 | |
| SCHEMBL10470453 | 0.76 | PTAFR (0.51) | CYP26A1MIFMEN1NPC1RAB9A | |
| SCHEMBL5753917 | 0.76 | CYP19A1 (0.48) | CYP26A1MIFKDM4ECYP19A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8592458-B2 | Alpha7 nicotinic receptor selective ligands | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-11-26 | — | — | US | disclosed |
| US-20120094943-A1 | ALPHA 7 NICOTINIC RECEPTOR SELECTIVE LIGANDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| US-8093269-B2 | Alpha 7 nicotinic receptor selective ligands | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2012-01-10 | — | — | US | disclosed |
| US-20090215705-A1 | Alpha 7 Nicotinic Receptor Selective Ligands | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| EP-1891036-A1 | ALPHA 7 NICOTINIC RECEPTOR SELECTIVE LIGANDS | University of Florida Research Foundation, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006133303-A1 | ALPHA 7 NICOTINIC RECEPTOR SELECTIVE LIGANDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215705-A1 | Alpha 7 Nicotinic Receptor Selective Ligands | CHRNA7, CHRNA10, CHRNA5 | CYP26A1 2172/4885MIF 3096/4885MEN1 3799/4885 |
| US-20120094943-A1 | ALPHA 7 NICOTINIC RECEPTOR SELECTIVE LIGANDS | CHRNA7, CHRNA10, CHRNA5 | CYP26A1 2172/4885MIF 3096/4885MEN1 3799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.