Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423278 | 0.84 | KDM4E (0.49) | KDM4ESMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL27955475 | 0.83 | ADORA3 (0.44) | KDM4ESMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL9620827 | 0.80 | KDM4E (0.61) | KDM4ESMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL316219 | 0.79 | SMN1; SMN2 (0.60) | KDM4ESMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL9620570 | 0.79 | APP (0.66) | KDM4ESMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL315601 | 0.76 | PARP1 (0.58) | KDM4ESMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL5417119 | 0.73 | KDM4E (0.49) | KDM4ESMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL14409229 | 0.73 | APP (0.51) | KDM4ESMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL9621138 | 0.73 | SMN1; SMN2 (0.52) | KDM4ESMN1; SMN2RAB9ANPC1PKM | |
| SCHEMBL2242816 | 0.72 | KDM4E (1.00) | KDM4ESMN1; SMN2RAB9ANPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093396-B2 | Benzthiazole inhibitors of poly(ADP-ribose)polymerase | ABBOTT LABORATORIES (US) | 2012-01-10 | — | — | US | disclosed |
| US-20100183743-A1 | BENZTHIAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2010-07-22 | — | — | US | disclosed |
| WO-2010083199-A1 | BENZTHIAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | ABBOTT LABORATORIES (US) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100183743-A1 | BENZTHIAZOLE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE | PARP1, PARP2, PARP6 | KDM4E 2965/4885SMN1; SMN2 782/4885RAB9A 3489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.