Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163394 | 0.93 | ADORA1 (0.51) | POLBLMNAADORA2AADORA1KMT2A | |
| SCHEMBL3168663 | 0.92 | ADORA1 (0.48) | POLBLMNAADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL3162824 | 0.91 | ADORA1 (0.47) | POLBLMNAADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL3168745 | 0.89 | ADORA2A (0.56) | LMNAADORA2AADORA1MEN1KMT2A | |
| SCHEMBL3156240 | 0.89 | RAB9A (0.51) | POLBLMNAADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL3155352 | 0.89 | ALDH1A1 (0.47) | LMNAADORA2AADORA1MEN1KMT2A | |
| SCHEMBL3170298 | 0.89 | ADORA2A (0.46) | POLBLMNAADORA2AADORA1MEN1 | |
| SCHEMBL3174346 | 0.89 | NPC1 (0.53) | POLBLMNAADORA2AADORA1MEN1 | |
| SCHEMBL3163156 | 0.89 | RAB9A (0.48) | POLBLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3164826 | 0.88 | CYP3A4 (0.49) | LMNAADORA2AADORA1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |