SCHEMBL3165337

SCHEMBL3165337

Cn1cc(C(F)(F)F)c(C(=O)O)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.44
HTR2C P28335 1/20 0.44
LMNA P02545 3/20 0.42
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
GAA P10253 1/20 0.40
PTGER1 P34995 1/20 0.38
TEAD1 P28347 1/20 0.36
TEAD4 Q15561 1/20 0.36
TEAD2 Q15562 1/20 0.36
TEAD3 Q99594 1/20 0.36
POLB P06746 2/20 0.36
ASPH Q12797 1/20 0.36
KMT2A Q03164 2/20 0.36
NTRK1 P04629 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2C9 P11712 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27672808 0.83 RAB9A (0.46) HTR2AHTR2CLMNANPC1RAB9A
SCHEMBL3675554 0.79 PTGER1 (0.45) LMNANPC1RAB9AGAAPTGER1
SCHEMBL3159391 0.76 ADORA2A (0.50) HTR2AHTR2CLMNANPC1RAB9A
SCHEMBL5118109 0.76 PTGER1 (0.46) HTR2AHTR2CNPC1RAB9AGAA
SCHEMBL1431330 0.76 L3MBTL1 (0.37) HTR2AHTR2CLMNAKMT2AL3MBTL1
SCHEMBL5423132 0.75 HTR2A (0.36) HTR2AHTR2CLMNANPC1RAB9A
SCHEMBL15189586 0.75 HTR2A (0.37) HTR2AHTR2CNPC1RAB9AGAA
SCHEMBL631704 0.74 KDM4E (0.39) LMNANPC1RAB9APTGER1KMT2A
SCHEMBL2805806 0.74 L3MBTL1 (0.41) HTR2ALMNAGAAL3MBTL1ALDH1A1
SCHEMBL19207142 0.73 HCRTR1 (0.48) TEAD1TEAD4TEAD2TEAD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7332518-B2 Carboxamides as fungicides in agriculture SYNGENTA CROP PROTECTION, INC. (US) 2008-02-19 US claimed
US-20040138265-A1 Carboxamides as fungicides in agriculture SYNGENTA CROP PROTECTION, INC. 2004-07-15 US claimed
CN-1498208-A Carboxamides as fungicides in agriculture �ӳɹ� 2004-05-19 CN claimed
EP-1355879-A1 CARBOXAMIDES AS FUNGICIDES IN AGRICULTURE Syngenta Participations AG (CH) 2003-10-29 EP claimed
WO-2002059086-A1 CARBOXAMIDES AS FUNGICIDES IN AGRICULTURE SYNGENTA PARTICIPATIONS AG (CH) 2002-08-01 WO claimed
US-20260042749-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2026-02-12 US disclosed
US-12545659-B2 IRAK degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2026-02-10 US disclosed
US-20240059674-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-02-22 US disclosed
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-09-28 US disclosed
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-09-28 US disclosed
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-09-28 US disclosed
US-20230069104-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-03-02 US disclosed
CN-101052628-A Isoxazolines derivatives and its weedicide application ZENECA LTD (GB) 2007-10-10 CN disclosed
EP-1789401-A1 ISOXAZOLINE DERIVATIVES AND THEIR USE AS HERBICIDES Syngenta Limited (GB) 2007-05-30 EP disclosed
WO-2007008895-A1 KINASE INHIBITORS ALLERGAN, INC. (US) 2007-01-18 WO disclosed
WO-2006024820-A1 ISOXAZOLINE DERIVATIVES AND THEIR USE AS HERBICIDES SYNGENTA LIMITED (GB) 2006-03-09 WO disclosed
US-20040138265-A1 Carboxamides as fungicides in agriculture SYNGENTA CROP PROTECTION, INC. 2004-07-15 US disclosed
CN-1498208-A Carboxamides as fungicides in agriculture �ӳɹ� 2004-05-19 CN disclosed
EP-1355879-A1 CARBOXAMIDES AS FUNGICIDES IN AGRICULTURE Syngenta Participations AG (CH) 2003-10-29 EP disclosed
WO-2002059086-A1 CARBOXAMIDES AS FUNGICIDES IN AGRICULTURE SYNGENTA PARTICIPATIONS AG (CH) 2002-08-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12545659-B2 IRAK degraders and uses thereof IRAK2, IRAK3, IRAK4 HTR2A 3531/4885HTR2C 3037/4885LMNA 2896/4885
US-20260042749-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK4 HTR2A 2247/4885HTR2C 1307/4885LMNA 3765/4885
US-20040138265-A1 Carboxamides as fungicides in agriculture CBR3, CBR1, CNPY3 HTR2A 1591/4885HTR2C 320/4885LMNA 2927/4885
US-20240059674-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 HTR2A 3621/4885HTR2C 4114/4885LMNA 1656/4885
US-20230069104-A1 IRAK DEGRADERS AND USES THEREOF IRAK4, IRAK2, IRAK3 HTR2A 4314/4885HTR2C 4423/4885LMNA 1420/4885
US-20230303526-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 HTR2A 3621/4885HTR2C 4114/4885LMNA 1656/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.