Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.35 |
| ▸ | JAK1 | P23458 | 4/20 | 0.32 |
| ▸ | JAK3 | P52333 | 4/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31662142 | 0.92 | IRAK4 (0.39) | IRAK4GCKMAPK1TBK1 | |
| SCHEMBL31662165 | 0.88 | IRAK4 (0.37) | SYKIRAK4JAK1JAK3JAK2 | |
| SCHEMBL31662129 | 0.86 | MAPK1 (0.38) | SYKIRAK4JAK1JAK3MAPK1 | |
| SCHEMBL31661957 | 0.86 | IRAK4 (0.36) | SYKIRAK4JAK1JAK3JAK2 | |
| SCHEMBL31661929 | 0.84 | IRAK4 (0.37) | SYKIRAK4JAK1JAK3JAK2 | |
| SCHEMBL31662279 | 0.83 | IRAK4 (0.37) | SYKIRAK4JAK1JAK3JAK2 | |
| SCHEMBL31662135 | 0.83 | IRAK4 (0.37) | SYKIRAK4JAK1JAK3JAK2 | |
| SCHEMBL31662162 | 0.83 | IRAK4 (0.37) | SYKIRAK4JAK1JAK3JAK2 | |
| SCHEMBL31662113 | 0.81 | SCN9A (0.39) | SYKIRAK4SCN9A | |
| SCHEMBL31661945 | 0.80 | LRRK2 (0.36) | MAPK1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | claimed |
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | disclosed |