Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31662165 | 0.96 | IRAK4 (0.37) | IRAK4SCN9AJAK1JAK3LRRK2 | |
| SCHEMBL31662099 | 0.91 | JAK1 (0.35) | IRAK4SCN9AJAK1JAK3LRRK2 | |
| SCHEMBL31662279 | 0.90 | IRAK4 (0.37) | IRAK4SCN9AJAK1JAK3LRRK2 | |
| SCHEMBL31662162 | 0.90 | IRAK4 (0.37) | IRAK4SCN9AJAK1JAK3LRRK2 | |
| SCHEMBL31662135 | 0.90 | IRAK4 (0.37) | IRAK4SCN9AJAK1JAK3LRRK2 | |
| SCHEMBL31661957 | 0.90 | IRAK4 (0.36) | IRAK4SCN9AJAK1JAK3LRRK2 | |
| SCHEMBL31662113 | 0.89 | SCN9A (0.39) | IRAK4SCN9ASYKROCK2HTR3A | |
| SCHEMBL31662042 | 0.89 | IRAK4 (0.41) | IRAK4SCN9AJAK1JAK3AR | |
| SCHEMBL31661945 | 0.88 | LRRK2 (0.36) | SCN9ALRRK2HRH3HTR3A | |
| SCHEMBL31662428 | 0.88 | DHODH (0.37) | LRRK2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | claimed |
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | disclosed |