Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 3/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.33 |
| ▸ | SELE | P16581 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | NMT1 | P30419 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31662412 | 0.92 | DRD4 (0.35) | SIGMAR1DRD4TMEM97CHRM1LRRK2 | |
| SCHEMBL31661929 | 0.91 | IRAK4 (0.37) | JAK1JAK3ARIRAK4SCN9A | |
| SCHEMBL31662165 | 0.89 | IRAK4 (0.37) | JAK1JAK3ARIRAK4SCN9A | |
| SCHEMBL31662162 | 0.84 | IRAK4 (0.37) | JAK1JAK3IRAK4SCN9AJAK2 | |
| SCHEMBL31662135 | 0.84 | IRAK4 (0.37) | JAK1JAK3IRAK4SCN9AJAK2 | |
| SCHEMBL31662279 | 0.84 | IRAK4 (0.37) | JAK1JAK3IRAK4SCN9AJAK2 | |
| SCHEMBL31661957 | 0.83 | IRAK4 (0.36) | JAK1JAK3IRAK4SCN9AJAK2 | |
| SCHEMBL31661953 | 0.83 | SCN9A (0.36) | JAK1JAK3SIGMAR1DRD4TMEM97 | |
| SCHEMBL31661886 | 0.82 | IRAK4 (0.39) | JAK1JAK3ARIRAK4SCN9A | |
| SCHEMBL31662113 | 0.82 | SCN9A (0.39) | SIGMAR1DRD4TMEM97IRAK4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | claimed |
| WO-2025149545-A1 | HETEROARYLPHENYL ETHER DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2025-07-17 | — | — | WO | disclosed |