SCHEMBL31662819

SCHEMBL31662819

O=Cc1ccc(I)cc1OC(F)F

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 2/20 0.43
DRD1 P21728 3/20 0.38
ALDH1A1 P00352 5/20 0.37
L3MBTL1 Q9Y468 1/20 0.35
HTT P42858 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
HPGD P15428 1/20 0.32
RAD51 Q06609 1/20 0.32
GAA P10253 2/20 0.31
MAPT P10636 1/20 0.31
LMNA P02545 1/20 0.31
KMT2A Q03164 1/20 0.31
NPSR1 Q6W5P4 1/20 0.30
PDE4A P27815 1/20 0.30
PDE4B Q07343 1/20 0.30
PDE4C Q08493 1/20 0.30
PDE4D Q08499 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11260550 0.80 ALDH1A1 (0.50) DRD1ALDH1A1L3MBTL1HTTSMN1; SMN2
SCHEMBL16793341 0.80 DRD1 (0.42) ERN1DRD1ALDH1A1L3MBTL1HTT
SCHEMBL17376694 0.79 ERN1 (0.43) ERN1DRD1ALDH1A1L3MBTL1HTT
SCHEMBL16797802 0.79 TDP1 (0.50) ERN1DRD1ALDH1A1L3MBTL1HTT
SCHEMBL18157268 0.79 SMN1; SMN2 (0.42) ERN1DRD1ALDH1A1L3MBTL1SMN1; SMN2
SCHEMBL30304192 0.79 TDP1 (0.50) ERN1DRD1ALDH1A1L3MBTL1HTT
SCHEMBL27890840 0.77 ERN1 (0.48) ERN1ALDH1A1L3MBTL1HTTSMN1; SMN2
SCHEMBL31098670 0.77 PDE4A (0.38) ALDH1A1HTTSMN1; SMN2HPGDMAPT
SCHEMBL266161 0.77 PDE4A (0.38) ALDH1A1HTTSMN1; SMN2HPGDMAPT
SCHEMBL29983926 0.76 KDM4E (0.40) DRD1ALDH1A1L3MBTL1HTTPDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025149498-A1 BENZYLPIPERIDINE DERIVATIVES AS TRP4 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES ASTRAZENECA AB (SE) 2025-07-17 WO disclosed