Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.72 |
| ▸ | KDR | P35968 | 5/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 4/20 | 0.54 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 5/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3185956 | 0.90 | SRC (0.60) | SRCKDRBRAFMAPK14TNNI3K | |
| SCHEMBL3166786 | 0.88 | RAF1 (0.62) | SRCKDRBRAFMAPK14TNNI3K | |
| SCHEMBL19911109 | 0.83 | SRC (1.00) | SRCKDRBRAFMAPK14TNNI3K | |
| SCHEMBL14453673 | 0.82 | SRC (0.58) | SRCKDRBRAFMAPK14TNNI3K | |
| SCHEMBL13528824 | 0.81 | SRC (0.60) | SRCKDRBRAFMAPK14TNNI3K | |
| SCHEMBL3166444 | 0.80 | KDR (0.68) | SRCKDRBRAFMAPK14TNNI3K | |
| SCHEMBL4938662 | 0.79 | KDR (0.55) | SRCKDRBRAFMAPK14TNNI3K | |
| SCHEMBL939171 | 0.78 | CDK8 (0.70) | SRCKDRBRAFMAPK14TNNI3K | |
| SCHEMBL5568335 | 0.78 | KDR (0.67) | SRCKDRBRAFMAPK14TNNI3K | |
| SCHEMBL25241289 | 0.78 | NPY2R (0.54) | KDRBRAFCSF1RFLT4PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652022-B2 | N-(4-(4-(4-hydroxyphenylamino)-pyrimidin-6-yl)-oxyphenyl)-N'-(3-trifluoromethylphenyl)-urea; | NOVARTIS AG (CH) | 2010-01-26 | — | — | US | disclosed |
| US-7652022-B2 | N-(4-(4-(4-hydroxyphenylamino)-pyrimidin-6-yl)-oxyphenyl)-N'-(3-trifluoromethylphenyl)-urea; | NOVARTIS AG (CH) | 2010-01-26 | — | — | US | disclosed |
| US-20060128734-A1 | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases | FLOERSHEIMER ANDREAS | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128734-A1 | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases | UCK2, PRKDC, PRKACA | SRC 849/4885KDR 3898/4885BRAF 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.