Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.68 |
| ▸ | BRAF | P15056 | 2/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.65 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.65 |
| ▸ | CDK8 | P49336 | 3/20 | 0.64 |
| ▸ | SRC | P12931 | 2/20 | 0.62 |
| ▸ | RAF1 | P04049 | 12/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | MUSK | O15146 | 1/20 | 0.56 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | MLNR | O43193 | 1/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | PDE6D | O43924 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL939171 | 0.86 | CDK8 (0.70) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL5568335 | 0.86 | KDR (0.67) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL30462521 | 0.85 | RAF1 (0.73) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL3181311 | 0.85 | RAF1 (0.70) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL936533 | 0.85 | RAF1 (0.73) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL12795164 | 0.85 | KDR (0.67) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL13885368 | 0.84 | RAF1 (0.80) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL29045853 | 0.83 | RAF1 (0.70) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL13528808 | 0.82 | SRC (0.59) | KDRBRAFMAPK14TNNI3KCDK8 | |
| SCHEMBL16907654 | 0.81 | KDR (1.00) | KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652022-B2 | N-(4-(4-(4-hydroxyphenylamino)-pyrimidin-6-yl)-oxyphenyl)-N'-(3-trifluoromethylphenyl)-urea; | NOVARTIS AG (CH) | 2010-01-26 | — | — | US | disclosed |
| US-7652022-B2 | N-(4-(4-(4-hydroxyphenylamino)-pyrimidin-6-yl)-oxyphenyl)-N'-(3-trifluoromethylphenyl)-urea; | NOVARTIS AG (CH) | 2010-01-26 | — | — | US | disclosed |
| US-20060128734-A1 | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases | FLOERSHEIMER ANDREAS | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128734-A1 | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases | UCK2, PRKDC, PRKACA | KDR 3898/4885BRAF 284/4885MAPK14 444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.