Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3166329 | 0.85 | LMNA (0.50) | LMNAMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL4803376 | 0.84 | LMNA (0.51) | LMNAMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL3157626 | 0.83 | LMNA (0.50) | LMNAMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL3166113 | 0.83 | LMNA (0.53) | LMNAMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL3171310 | 0.82 | MAPT (0.53) | LMNAMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL3166048 | 0.77 | CSNK1D (0.51) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL3172806 | 0.77 | RAB9A (0.66) | LMNAMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL3167505 | 0.75 | MAPT (0.53) | LMNAMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL3157431 | 0.75 | NPC1 (0.48) | LMNAMAPTTP53ALDH1A1RAB9A | |
| SCHEMBL3172964 | 0.74 | PARP1 (0.47) | LMNAMAPTALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716128-B1 | SUBSTITUTED 4,5,6,7-TETRAHYDRO-BENZOTHIAZOL-2-YLAMINE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2010-03-31 | — | — | EP | claimed |