⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL317056 | 0.73 | — | — | |
| SCHEMBL22344982 | 0.70 | — | — | |
| SCHEMBL16503647 | 0.63 | — | — | |
| SCHEMBL12458637 | 0.63 | ALDH1A1 (0.38) | — | |
| SCHEMBL20745198 | 0.62 | CYP1A2 (0.50) | — | |
| SCHEMBL15663034 | 0.62 | ESR1 (0.33) | — | |
| SCHEMBL1666899 | 0.61 | ALDH1A1 (0.34) | — | |
| SCHEMBL12457457 | 0.61 | HASPIN (0.30) | — | |
| SCHEMBL21840508 | 0.61 | ALDH1A1 (0.43) | — | |
| SCHEMBL1949798 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090334-B1 | Imidazole based compounds, compositions comprising them and methods of their use | LEXICON PHARMACEUTICALS INC (US) | 2015-04-29 | — | — | EP | disclosed |
| US-8404732-B2 | Methods of treating ulcerative colitis | LEXICON PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-20130005775-A1 | METHODS OF TREATING ULCERATIVE COLITIS | LEXICON PHARMACEUTICALS, INC. (US) | 2013-01-03 | — | — | US | disclosed |
| US-8093267-B2 | Methods of treating rheumatoid arthritis | LEXICON PHARMACEUTICALS, INC. (US) | 2012-01-10 | — | — | US | disclosed |
| EP-2367551-A1 | S1P LYASE INHIBITORS FOR THE TREATMENT OF CEREBRAL MALARIA | Lexicon Pharmaceuticals, Inc. (US) | 2011-09-28 | — | — | EP | disclosed |
| US-7825150-B2 | Compositions and methods for treating immunological and inflammatory diseases and disorders | LEXICON PHARMACEUTICALS, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| EP-2182944-A1 | COMPOSITIONS AND METHODS FOR TREATING IMMUNOLOGICAL AND INFLAMMATORY DISEASES AND DISORDERS | Lexicon Pharmaceuticals, Inc. (US) | 2010-05-12 | — | — | EP | disclosed |
| US-20100113530-A1 | S1P LYASE INHIBITORS FOR THE TREATMENT OF CEREBRAL MALARIA | LEXICON PHARMACEUTICALS, INC. | 2010-05-06 | — | — | US | disclosed |
| WO-2010051353-A1 | S1P LYASE INHIBITORS FOR THE TREATMENT OF CEREBRAL MALARIA | LEXICON PHARMACEUTICALS, INC. (US) | 2010-05-06 | — | — | WO | disclosed |
| US-20100076030-A1 | METHODS OF TREATING RHEUMATOID ARTHRITIS | LEXICON PHARMACEUTICALS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-7649098-B2 | Imidazole-based compounds, compositions comprising them and methods of their use | LEXICON PHARMACEUTICALS, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| EP-2090334-A2 | Imidazole based compounds, compositions comprising them and methods of their use | Lexicon Pharmaceuticals, Inc. (US) | 2009-08-19 | — | — | EP | disclosed |
| US-20090068180-A1 | COMPOSITIONS AND METHODS FOR TREATING IMMUNOLOGICAL AND INFLAMMATORY DISEASES AND DISORDERS | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2009-03-12 | — | — | US | disclosed |
| WO-2009032972-A1 | COMPOSITIONS AND METHODS FOR TREATING IMMUNOLOGICAL AND INFLAMMATORY DISEASES AND DISORDERS | LEXICON PHARMACEUTICALS, INC. (US) | 2009-03-12 | — | — | WO | disclosed |
| EP-2010501-A2 | IMIDAZOLE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007100617-A2 | IMIDAZOLE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |
| US-20070208063-A1 | Imidazole-based compounds, compositions comprising them and methods of their use | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2007-09-06 | — | — | US | disclosed |