SCHEMBL31664070

SCHEMBL31664070

COc1cc(C)c(N)cc1OCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.49
MAPT P10636 1/20 0.49
MAPK1 P28482 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
HPGD P15428 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
SRD5A1 P18405 2/20 0.47
SRD5A2 P31213 2/20 0.47
CTSV O60911 1/20 0.47
CTSL P07711 1/20 0.47
SMPD1 P17405 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
HTR1A P08908 1/20 0.47
ADRA1D P25100 1/20 0.47
ADRA1A P35348 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21070386 1.00 CHRNA7 (0.49) CHRNA7MAPTMAPK1TDP1L3MBTL1
SCHEMBL31757025 0.87 CHRNA7 (0.51) CHRNA7NPC1RAB9AHPGDSMN1; SMN2
SCHEMBL15949806 0.86 MEN1 (0.53) CHRNA7MAPTL3MBTL1NPC1RAB9A
SCHEMBL11223475 0.85 NPC1 (0.51) CHRNA7MAPTMAPK1TDP1L3MBTL1
SCHEMBL20562352 0.84 MEN1 (0.54) CHRNA7MAPTMAPK1TDP1L3MBTL1
SCHEMBL4596187 0.84 MEN1 (0.54) CHRNA7MAPTMAPK1TDP1L3MBTL1
SCHEMBL31757004 0.81 MAPT (0.49) MAPTMAPK1TDP1L3MBTL1NPC1
SCHEMBL30739394 0.81 MAPT (0.49) MAPTMAPK1TDP1L3MBTL1RAB9A
SCHEMBL8313819 0.81 LTA4H (0.56) MAPTMAPK1TDP1L3MBTL1RAB9A
SCHEMBL4644108 0.80 L3MBTL1 (0.55) MAPTMAPK1TDP1L3MBTL1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4613773-A2 IRAK DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2025-09-10 EP disclosed
EP-3731869-B1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2025-07-23 EP disclosed