Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.52 |
| ▸ | SYK | P43405 | 6/20 | 0.50 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30751554 | 0.90 | PTPN11 (0.47) | JAK2JAK1TYK2JAK3PTPN11 | |
| SCHEMBL30751511 | 0.89 | PTPN11 (0.53) | MAP4K1SYKCAMK1DJAK2JAK1 | |
| SCHEMBL31673015 | 0.85 | CAMK1D (0.48) | SYKCAMK1DPTPN11 | |
| Hydrochloric Acid SCHEMBL31673025 | 0.84 | HTR2A (0.55) | MAP4K1CAMK1DJAK2JAK1TYK2 | |
| SCHEMBL30751502 | 0.83 | SYK (0.45) | SYKCAMK1DJAK1TYK2PTPN11 | |
| SCHEMBL31673033 | 0.82 | MAP4K1 (0.51) | MAP4K1SYKCAMK1DJAK2JAK1 | |
| SCHEMBL31673027 | 0.81 | MAP4K1 (0.56) | MAP4K1SYKCAMK1DJAK2JAK1 | |
| SCHEMBL30751495 | 0.79 | PTPN11 (0.52) | JAK2JAK1TYK2PTPN11ALK | |
| SCHEMBL30751569 | 0.78 | PTPN11 (0.57) | MAP4K1CAMK1DJAK2JAK1TYK2 | |
| SCHEMBL30751519 | 0.78 | SYK (0.56) | SYKCAMK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250257051-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AS TYK2 INHIBITORS | 1910 GENETICS INC (US) | 2025-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250257051-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AS TYK2 INHIBITORS | TYK2, PDXK, JAK1 | MAP4K1 116/4885SYK 201/4885CAMK1D 667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.