Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.49 |
| ▸ | CKS1B | P61024 | 1/20 | 0.47 |
| ▸ | SKP1 | P63208 | 1/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.47 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CCNK | O75909 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30751495 | 0.91 | PTPN11 (0.52) | PTPN11JAK2JAK1TYK2CKS1B | |
| SCHEMBL31673019 | 0.89 | MAP4K1 (0.52) | PTPN11JAK2JAK1TYK2JAK3 | |
| SCHEMBL30751544 | 0.88 | PTPN11 (0.52) | PTPN11MAP4K1CKS1BSKP1SKP2 | |
| SCHEMBL30751560 | 0.84 | PTPN11 (0.45) | PTPN11JAK1TYK2CKS1BSKP1 | |
| SCHEMBL30751488 | 0.84 | JAK2 (0.49) | JAK2JAK1TYK2JAK3MAP4K1 | |
| SCHEMBL30751493 | 0.80 | SYK (0.49) | PTPN11CAMK1DPDE4BSYK | |
| Hydrochloric Acid SCHEMBL31673025 | 0.80 | HTR2A (0.55) | JAK2JAK1TYK2JAK3MAP4K1 | |
| SCHEMBL30751554 | 0.79 | PTPN11 (0.47) | PTPN11JAK2JAK1TYK2JAK3 | |
| SCHEMBL30751534 | 0.79 | PTPN11 (0.51) | PTPN11JAK2JAK1TYK2CKS1B | |
| SCHEMBL31673027 | 0.78 | MAP4K1 (0.56) | JAK2JAK1TYK2JAK3MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250257051-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AS TYK2 INHIBITORS | 1910 GENETICS INC (US) | 2025-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250257051-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AS TYK2 INHIBITORS | TYK2, PDXK, JAK1 | PTPN11 535/4885JAK2 5/4885JAK1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.