Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31678727 | 0.91 | AKR1B1 (0.41) | AKR1B1MAPTTP53KDM4EFPR2 | |
| SCHEMBL31678102 | 0.89 | KDM4E (0.40) | AKR1B1MAPTTP53KDM4EFPR2 | |
| SCHEMBL31678828 | 0.88 | AKR1B1 (0.38) | AKR1B1MAPTTP53LMNAHTT | |
| SCHEMBL31677806 | 0.87 | AKR1B1 (0.40) | AKR1B1MAPTTP53LMNAKDM4E | |
| SCHEMBL31677840 | 0.87 | MAPT (0.39) | AKR1B1MAPTTP53LMNAHTT | |
| SCHEMBL31653720 | 0.86 | ALDH1A1 (0.42) | AKR1B1MAPTTP53LMNAHTT | |
| SCHEMBL31678841 | 0.86 | MAPT (0.39) | AKR1B1MAPTTP53LMNAHTT | |
| SCHEMBL31677890 | 0.85 | ACHE (0.41) | MAPTTP53LMNAKDM4EKMT2A | |
| SCHEMBL31678116 | 0.83 | AKR1B1 (0.40) | AKR1B1MAPTTP53KDM4EFPR2 | |
| SCHEMBL31664558 | 0.83 | AKR1B1 (0.42) | AKR1B1MAPTTP53KDM4EFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250270218-A1 | IMIDAZ0[1,2-A]PYRIMIDINE-5(1 H)-ONES AS WRN INHIBITORS | INCYTE CORPORATION (US) | 2025-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250270218-A1 | IMIDAZ0[1,2-A]PYRIMIDINE-5(1 H)-ONES AS WRN INHIBITORS | WRN, RECQL, BLM | AKR1B1 2350/4885MAPT 4574/4885TP53 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.