Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK2 | P53671 | 2/20 | 0.67 |
| ▸ | SCN8A | Q9UQD0 | 7/20 | 0.59 |
| ▸ | SCN1A | P35498 | 4/20 | 0.59 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.59 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.59 |
| ▸ | SCN4A | P35499 | 1/20 | 0.59 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.59 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.59 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.59 |
| ▸ | SCN1B | Q07699 | 6/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163253 | 0.89 | SCN8A (0.56) | LIMK2SCN8ASCN1ASCN5ASCN3A | |
| SCHEMBL3166893 | 0.89 | SCN8A (0.56) | LIMK2SCN8ASCN1ASCN5ASCN3A | |
| SCHEMBL3166883 | 0.89 | SCN8A (0.56) | LIMK2SCN8ASCN1ASCN5ASCN3A | |
| SCHEMBL3163245 | 0.89 | SCN8A (0.56) | LIMK2SCN8ASCN1ASCN5ASCN3A | |
| SCHEMBL3165520 | 0.85 | SCN3A (0.59) | LIMK2SCN8ASCN1ASCN5ASCN3A | |
| SCHEMBL3165535 | 0.85 | SCN8A (0.54) | LIMK2SCN8ASCN1ASCN5ASCN3A | |
| SCHEMBL3167341 | 0.83 | SCN1A (0.54) | LIMK2SCN8ASCN1ASCN5ASCN3A | |
| SCHEMBL3168125 | 0.83 | SCN8A (0.56) | LIMK2SCN8ASCN1ASCN5ASCN3A | |
| SCHEMBL3173762 | 0.82 | SCN3A (0.65) | SCN8ASCN1ASCN5ASCN3ASCN4A | |
| SCHEMBL3169340 | 0.82 | SCN3A (0.65) | SCN8ASCN1ASCN5ASCN3ASCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741934-B2 | Inhibitors of ion channels | PFIZER LIMITED (GB) | 2014-06-03 | — | — | US | disclosed |
| US-20130072471-A1 | Inhibitors of Ion Channels | MARRON BRIAN EDWARD (US) | 2013-03-21 | — | — | US | disclosed |
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| EP-1995241-B1 | Inhibitors of ion channels | ICAGEN INC (US) | 2010-03-17 | — | — | EP | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| EP-1995241-A1 | Inhibitors of ion channels | ICAgen, Incorporated (US) | 2008-11-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072471-A1 | Inhibitors of Ion Channels | TRPV1, TRPV5, TRPA1 | LIMK2 2137/4885SCN8A 75/4885SCN1A 6/4885 |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | LIMK2 2137/4885SCN8A 75/4885SCN1A 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.