Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 2/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23914672 | 0.86 | GAA (0.49) | GAAALDH1A1L3MBTL1TSHRTDP1 | |
| SCHEMBL10423854 | 0.81 | TSHR (0.47) | GAAALDH1A1L3MBTL1TSHRTDP1 | |
| SCHEMBL25659027 | 0.81 | NPC1 (0.55) | GAAALDH1A1L3MBTL1TSHRTDP1 | |
| SCHEMBL8876498 | 0.77 | GAA (0.44) | GAAALDH1A1L3MBTL1TSHRTDP1 | |
| SCHEMBL7162693 | 0.76 | ALDH1A1 (0.52) | GAAALDH1A1L3MBTL1TSHRLMNA | |
| SCHEMBL3165624 | 0.74 | GAA (0.67) | GAAALDH1A1L3MBTL1TSHRTDP1 | |
| SCHEMBL22714369 | 0.72 | TSHR (0.43) | GAAALDH1A1L3MBTL1TSHRTDP1 | |
| SCHEMBL17366264 | 0.72 | ALDH1A1 (0.69) | GAAALDH1A1L3MBTL1TSHRTDP1 | |
| SCHEMBL5880864 | 0.72 | TSHR (0.57) | GAAALDH1A1TSHRTDP1LMNA | |
| SCHEMBL5241392 | 0.72 | CNR2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645760-B2 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG. (CH) | 2010-01-12 | — | — | US | disclosed |
| CN-101570517-A | 1- (4-benzyl-piperazin-1-yl) -3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2009-11-04 | — | — | CN | disclosed |
| CN-100554257-C | 1- (4-benzyl-piperazin-1-yl) -3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2009-10-28 | — | — | CN | disclosed |
| US-20060173004-A1 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2006-08-03 | — | — | US | disclosed |
| CN-1708489-A | 1- (4-benzyl-piperazin-1-yl) -3-phenyl-propenone derivatives | NOVARTIS AG (CH) | 2005-12-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173004-A1 | 1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives | CCR1, CCR3, CCR4 | GAA 2953/4885ALDH1A1 290/4885L3MBTL1 2266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.