Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.67 |
| ▸ | CTSK | P43235 | 5/20 | 0.67 |
| ▸ | CTSL | P07711 | 4/20 | 0.67 |
| ▸ | CTSB | P07858 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 4/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3168779 | 0.96 | CTSS (0.71) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL3168821 | 0.95 | CTSS (0.70) | CTSSCTSKCTSLCTSBHDAC6 | |
| Hydrochloric Acid SCHEMBL3169383 | 0.95 | CTSS (0.70) | CTSSCTSKCTSLCTSBHDAC6 | |
| Fumaric Acid SCHEMBL3166690 | 0.93 | CTSS (0.66) | CTSSCTSKCTSLCTSBHDAC6 | |
| Fumaric Acid SCHEMBL3166701 | 0.93 | CTSS (0.66) | CTSSCTSKCTSLCTSBHDAC6 | |
| Trifluoroacetic Acid SCHEMBL3174605 | 0.92 | CTSS (0.65) | CTSSCTSKCTSLCTSBHDAC6 | |
| Trifluoroacetic Acid SCHEMBL3180549 | 0.92 | CTSS (0.64) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL3174455 | 0.90 | CTSS (0.64) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL3165989 | 0.90 | CTSS (0.66) | CTSSCTSKCTSLCTSBHDAC6 | |
| SCHEMBL3176619 | 0.90 | CTSS (0.68) | CTSSCTSKCTSLCTSBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009956-A1 | NOVEL SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | Glaxo Group Limited , a corporation | 2010-01-14 | — | — | US | claimed |
| US-20100009956-A1 | NOVEL SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | Glaxo Group Limited , a corporation | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009956-A1 | NOVEL SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | SERPINB1, CTRL, PRSS1 | CTSS 15/4885CTSK 65/4885CTSL 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.