Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 5/20 | 0.42 |
| ▸ | F13A1 | P00488 | 3/20 | 0.42 |
| ▸ | TGM1 | P22735 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1870570 | 0.84 | NR1H2 (0.54) | PTPN2PTPN1PTPN6ALDH1A1GRM5 | |
| SCHEMBL14720896 | 0.84 | GRM5 (0.46) | ALDH1A1GRM5NPC1RAB9AMAPT | |
| SCHEMBL4635083 | 0.84 | GRM5 (0.46) | GRM5GPR119ESR2MEN1KMT2A | |
| SCHEMBL5497099 | 0.84 | MEN1 (0.55) | ALDH1A1GRM5HTTESR2MEN1 | |
| SCHEMBL1473227 | 0.84 | GPR119 (0.51) | GRM5MAPK1GPR119ESR2NR1H2 | |
| SCHEMBL1602307 | 0.84 | OGA (0.46) | ALDH1A1GRM5MAPTGPR119MEN1 | |
| SCHEMBL20304919 | 0.83 | SRD5A2 (0.55) | GRM5MAPTGPR119ESR2MEN1 | |
| SCHEMBL15699606 | 0.83 | ALDH1A1 (0.54) | ALDH1A1GRM5MAPTHTTGPR119 | |
| SCHEMBL16113569 | 0.82 | MAPT (0.54) | GRM5MAPTGPR119ESR2NR1H2 | |
| SCHEMBL4974215 | 0.82 | GPR119 (0.55) | PTPN2PTPN1PTPN6ALDH1A1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250325677-A1 | STAT6 DEGRADERS | GILEAD SCIENCES INC (US) | 2025-10-23 | — | — | US | disclosed |
| US-20250320205-A1 | STAT6 DEGRADERS | GILEAD SCIENCES INC (US) | 2025-10-16 | — | — | US | disclosed |
| US-20250320206-A1 | STAT6 DEGRADERS | GILEAD SCIENCES INC (US) | 2025-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250325677-A1 | STAT6 DEGRADERS | STAT6, STAT5B, STAT1 | PTPN2 693/4885PTPN1 789/4885PTPN6 497/4885 |
| US-20250320205-A1 | STAT6 DEGRADERS | STAT6, STAT1, STAT5B | PTPN2 569/4885PTPN1 675/4885PTPN6 447/4885 |
| US-20250320206-A1 | STAT6 DEGRADERS | STAT6, STAT5B, STAT1 | PTPN2 693/4885PTPN1 789/4885PTPN6 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.