Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3170212 | 0.83 | HPGD (0.63) | HPGDSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL3870652 | 0.74 | HPGD (0.71) | HPGDSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL3174328 | 0.73 | HPGD (0.74) | HPGDSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL3154775 | 0.73 | RAB9A (0.68) | HPGDSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL3163742 | 0.72 | HPGD (0.71) | HPGDSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL3729005 | 0.72 | KDM4E (0.47) | SMN1; SMN2KMT2AALDH1A1MEN1HTT | |
| SCHEMBL7560143 | 0.71 | HPGD (0.62) | HPGDSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL6642363 | 0.70 | NPC1 (0.59) | HPGDSMN1; SMN2RAB9ANPC1KMT2A | |
| SCHEMBL4218764 | 0.69 | CYP1A2 (0.35) | MAPTGAAHRH3BACE1KDM4E | |
| SCHEMBL6963144 | 0.69 | MAPT (0.47) | HPGDSMN1; SMN2RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1630165-B1 | [1,2,4]TRIAZOLO[1,5-a]PYRIMIDIN-2-YLUREA DERIVATIVE AND USE THEREOF | NIPPON KAYAKU KK (JP) | 2010-03-31 | — | — | EP | disclosed |