Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 15/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 15/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 15/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | IDE | P14735 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL31706661 | 1.00 | TLR9 (0.46) | TLR9TLR8TLR7HTR2BALDH1A1 | |
| Lithium Ion SCHEMBL31706258 | 0.90 | TLR9 (0.43) | TLR9TLR8TLR7 | |
| Lithium Ion SCHEMBL31706750 | 0.90 | TLR9 (0.43) | TLR9TLR8TLR7 | |
| SCHEMBL31706149 | 0.87 | TLR9 (0.48) | TLR9TLR8TLR7HTR2BALDH1A1 | |
| SCHEMBL31705266 | 0.84 | TLR8 (0.48) | TLR9TLR8TLR7ALDH1A1CFTR | |
| Lithium Ion SCHEMBL21633065 | 0.83 | LNPEP (0.37) | ALDH1A1 | |
| Lithium Ion SCHEMBL31705981 | 0.80 | TDP1 (0.51) | ALDH1A1IDEMAPK1 | |
| Lithium Ion SCHEMBL31704941 | 0.80 | TDP1 (0.51) | ALDH1A1IDEMAPK1 | |
| Lithium Ion SCHEMBL31706495 | 0.78 | TLR9 (0.43) | TLR9TLR8TLR7 | |
| SCHEMBL31705122 | 0.78 | TLR9 (0.44) | TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215110-A1 | NEW AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS SOS1 INHIBITORS | LES LABORATOIRES SERVIER (FR) | 2025-10-16 | — | — | WO | disclosed |